Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid

Journal of Chromatography. a
Rocío García-VillalbaFrancisco Tomás-Barberán

Abstract

Ellagitannins and ellagic acid (EA) are metabolized by the gut microbiota to produce urolithins that could be responsible for the health effects attributed to ellagitannin-containing food products. Several urolithin aglycones could be present in fecal samples while glucuronide and sulphate conjugates are mainly found in plasma and urine. So far, the lack of available standards has made difficult their correct identification and quantification. In the present study, UV and MS spectra characteristics of urolithins and their phase II metabolites have been determined using different systems based on liquid chromatography (LC) coupled with diode-array or mass spectrometer detectors with different analyzers (triple quadrupole (QqQ) and quadrupole time-of-flight (QTOF)). Chromatographic separation was achieved on a reversed-phase Poroshell C18 column (3×100mm, 2.7μm). Elution order, characteristic UV spectra, and relative response factors (RRFs) with respect to their parental compound (EA) and the most common metabolite urolithin A (Uro-A) were determined. This contribution, along with the most important mass spectra characteristics (MRM transitions, qualifier/quantifier ratio, accurate mass and fragmentation pattern) will allow the d...Continue Reading

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Citations

Mar 21, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María Ángeles Núñez-SánchezJuan Carlos Espín
Jan 23, 2016·Journal of Pharmaceutical and Biomedical Analysis·Johan ViaeneYvan Vander Heyden
Mar 28, 2018·International Journal of Systematic and Evolutionary Microbiology·David BeltránMaria V Selma
Nov 5, 2016·Molecular Nutrition & Food Research·Kristen M RobertsSteven K Clinton
Nov 18, 2018·Molecular Nutrition & Food Research·Adrián Cortés-MartínRocío García-Villalba
May 8, 2019·International Journal of Food Sciences and Nutrition·Iza F Pérez-RamírezJara Pérez-Jiménez
Mar 12, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jakub P PiwowarskiAnna K Kiss
Apr 9, 2020·Experimental and Therapeutic Medicine·Su-Hui WuYue-Juan Qi
Jun 21, 2020·Genes & Nutrition·N Vázquez-ManjarrezC Manach
Mar 30, 2019·Genes & Nutrition·Mar Garcia-AloyCristina Andres-Lacueva
May 26, 2017·International Journal of Food Sciences and Nutrition·Milica KojadinovicMilica Popovic
Aug 22, 2017·Frontiers in Microbiology·María V SelmaFrancisco A Tomás-Barberán
Dec 31, 2020·International Journal of Environmental Research and Public Health·Ashley Mulcahy ToneySoonkyu Chung
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Emilia Szabłowska, Małgorzata Tańska
Jul 11, 2020·Journal of Agricultural and Food Chemistry·Jakub MacierzyńskiElżbieta Karlińska
Dec 23, 2016·Journal of Natural Products·Jakub P PiwowarskiAnna K Kiss
Oct 20, 2018·Journal of Agricultural and Food Chemistry·Xiao Yang, Francisco A Tomás-Barberán
Sep 10, 2019·Journal of Agricultural and Food Chemistry·Rocío García-VillalbaFrancisco A Tomás-Barberán
Dec 30, 2020·Journal of Agricultural and Food Chemistry·Maite Domínguez-FernándezAna Rodriguez-Mateos

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