Chromatographic modelling of interactions between melanin and phenothiazine and dibenzazepine drugs

Biomedical Chromatography : BMC
A RadwańskaR Kaliszan

Abstract

Differences in drug-melanin interactions were determined for 13 phenothiazine neuroleptics and 2 dibenzazepine thymoleptics by means of high-performance liquid chromatography. The chromatographic column was packed with a stationary phase obtained by chemical immobilization of synthetic L-dopa melanin on silica particles. For six phenothiazines the melanin-binding parameters were also determined by an ultrafiltration method. Correlation between measures of drug-melanin interaction determined chromatographically and by the standard slow-equilibrium method was significant, however moderate. The chromatographic method of assessing interactions between drugs and melanin permitted reliable and quantitatively comparable data for representative series of solutes to be readily obtained. Such data were subjected to the analysis of quantitative structure-retention relationships (QSRR). It was found that retention of the agents on the immobilized melanin column could be described by two-parameter regression equations comprising the energy of the lowest unoccupied molecular orbital and either the water-accessible surface area of a drug molecule or its hydrophobicity parameter, determined chromatographically on an immobilized artificial memb...Continue Reading

References

Apr 1, 1979·Biochemical Pharmacology·B Larsson, H Tjälve
Nov 1, 1977·Journal of Pharmaceutical Sciences·R BawejaP N Patil
Jan 15, 1990·Experientia·P R RaghavanS L Tripp
Oct 1, 1988·Medicinal Research Reviews·G Prota
Jan 1, 1970·Acta Psychiatrica Scandinavica·E ChristensenA Faurbye
Nov 1, 1982·Biochemical Pharmacology·K B Stepień, T Wilczok
Jul 1, 1981·Biochemical Pharmacology·H TjälveB Larsson
Jan 1, 1994·Journal of Ocular Pharmacology·M M Salazar-BookamanP N Patil
Jun 1, 1993·Pigment Cell Research·B S Larsson

❮ Previous
Next ❯

Citations

Apr 10, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·David S Hage
Apr 10, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Michal Markuszewski, Roman Kaliszan
Apr 10, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Anne-Françoise Aubry
Oct 29, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·R Kaliszan
Dec 16, 2000·Pharmaceutical Science & Technology Today·T Geetha, S Singh
Apr 3, 1999·Journal of Pharmaceutical Sciences·B H Stewart, O H Chan
Nov 7, 2018·Journal of Medicinal Chemistry·Paulina JakubiakRubén Alvarez-Sánchez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here