PMID: 9541121Apr 16, 1998Paper

Chromatographically identified alcohol-induced haemoglobin adducts as markers of alcohol abuse among women

European Journal of Clinical Investigation
L HurmeP Sillanaukee

Abstract

Alcohol-induced changes in haemoglobin have been suggested as potential biochemical markers of alcohol abuse. In this study, we investigated the diagnostic value of alcohol-induced haemoglobin adducts among women. Whole (Hb fractions) and affinity-purified (AHb fractions) haemolysates from 87 women in three groups (a) social drinkers (n=31), (b) heavy drinkers (n=27) and (c) alcoholic subjects (n=29) - were analysed by HPLC-CEC. Three fractions (HbA 1a2, HbA1dl and AHbA1d1) showed significant differences (P<0.05) between the groups and a significant positive correlation (P<0.05) with self-reported alcohol consumption (r=0.58-0.76) as determined by the Malmö modified Michigan Alcoholism Screening Test (MmMAST) and structured CAGE questionnaire (r=0.58-0.76). HbA1a2, HbA1d1 and AHbA1d1 had specificities of 97%, 97% and 100% respectively and detected 41%, 33% and 78% of heavy drinkers with overall accuracies (OAs) of 71%, 67% and 90%. Sensitivities in the detection of alcoholic subjects were 86% (OA=92%), 76% (OA=87%) and 81 % (OA=91%) respectively. The fractions had higher OAs than traditional markers of alcohol abuse. This study indicates that at least three alcohol-induced haemoglobin adducts occurring in vivo can be measured w...Continue Reading

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Citations

Sep 4, 2012·Clinics in Laboratory Medicine·Glynnis B Ingall
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Frank Musshoff

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