Jan 21, 2016

Chromes from Chromatin: Sonification of the Epigenome

BioRxiv : the Preprint Server for Biology
Davide CittaroPaolo Provero

Abstract

The epigenetic modifications are organized in patterns determining the functional properties of the underlying genome. Such patterns, typically measured by ChIP-seq assays of histone modifications, can be combined and translated into musical scores, summarizing multiple signals into a single waveform. As music is recognized as a universal way to convey meaningful information (1), we wanted to investigate properties of music obtained by sonification of ChIP-seq data. We show that the music produced by such quantitative signals is perceived by human listener as more pleasant than that produced from randomized signals. Moreover, the waveform can be analyzed to predict phenotypic properties, such as differential gene expression.

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Mentioned in this Paper

Patterns
Genome
Tissue-Specific Gene Expression
Chromatin Immunoprecipitation
Gene Expression
Study of Epigenetics
Histone Modification
Chromatin Location
Analysis
Chromatin

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