PMID: 6787741Mar 1, 1981

Chromium genotoxicity as influenced by complexation and rate effects

Toxicology Letters
J M GentileJ Schubert

Abstract

Conclusions as to the mutagenicity and carcinogenicity of metal salts can be ambiguous and misleading, especially for metal ions having a high charge/radius ratio, hence a strong tendency to hydrolyze. Using the rec-assay, we determined whether the mutagenicity of chromium salts was reduced by complexation, as in the case of Cr(VI), or induced in the case of Cr(III). We find that several chelants, in proportion to concentration, reduce or eliminate the mutagenicity of Cr2O32-. These include EDTA, salicylate (SA), and Tiron (disodium 1,2-dihydroxylbenzene-3,5-disulfonate). Cr(III) was rendered slightly mutagenic by salicylate and citrate. None of the chelating agents or their combinations were mutagenic.

References

May 30, 1978·Biochemical and Biophysical Research Communications·J E Gruber, K W Jennette
Oct 1, 1978·Mutation Research·F L Petrilli, S de Flora
Nov 1, 1978·Mutation Research·F L Petrilli, S de Flora
Aug 1, 1979·Chemico-biological Interactions·R F WhitingD J Koropatnick
Aug 1, 1979·Chemico-biological Interactions·W D MacRaeH F Stich
Jun 1, 1975·Mutation Research·H Nishioka
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M A Sirover, L A Loeb
Dec 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·W J VISEKC L COMAR
Mar 1, 1979·Biological Trace Element Research·K W Jennette

Citations

Jun 1, 1988·The Science of the Total Environment·V Bianchi, A G Levis
Mar 1, 1990·Mutation Research·S de FloraP Zanacchi
May 1, 1988·Mutation Research·M D WatersN E Garrett
Mar 1, 1986·Environmental Health Perspectives·P O Ganrot
Aug 1, 1981·Environmental Health Perspectives·J Schubert
Oct 1, 1985·Journal of Applied Toxicology : JAT·K Hansen, R M Stern
Jan 1, 1985·Environmental Mutagenesis·N LoprienoA G Levis

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