PMID: 6989697Mar 1, 1980Paper

Chromium-induced inhibition of insulin secretion from isolated islets of Langerhans

Diabetologia
T GhafghaziP E Lacy

Abstract

CrCl3, 0.25, 0.5, 1.0, and 1.5 mmol/l inhibited glucose-induced insulin secretion in a reversible and dose dependent manner. Cr also inhibited basal secretion of insulin in the presence of 5.5 mmol/l glucose and insulin secretion stimulated by 50 mmol/l K+ or 15 mmol/l L-leucine. When 2 mmol/l theophylline was employed to potentiate the stimulatory effect of 16.5 mmol/l glucose, the inhibitory effect of 1.5 mmol/l Cr was reduced and that of 0.5 mmol/l virtually abolished. A similar reduction in the inhibitory effect of Cr was observed when the medium calcium concentration was increased from 2.5 to 5, 7.5 and 12.5 mmol/l. Cr did not alter the conversion of 14C-glucose to 14CO2 or 45Ca uptake by isolated islets. It is concluded that the inhibitory effect of Cr on insulin secretion may be mediated through interference with an intracellular function of Ca++ in the beta cell.

References

Jan 1, 1979·Toxicology·T GhafghaziR Barnett
Nov 3, 1978·JAMA : the Journal of the American Medical Association·A Wise
May 1, 1968·Metabolism: Clinical and Experimental·L ShermanE S Gordon
Apr 1, 1969·Physiological Reviews·W Mertz
Feb 1, 1968·Metabolism: Clinical and Experimental·R A LevineR J Doisy

Citations

Aug 1, 1980·Diabetologia·D Shapcott
Dec 1, 1983·Biological Trace Element Research·M B RabinowitzM B Davidson
Jun 26, 2009·Biological Trace Element Research·Beob G KimMerlin D Lindemann
Feb 24, 2000·Toxicology·M J Solis-HerediaA Albores
Mar 1, 1986·Environmental Health Perspectives·P O Ganrot
Oct 1, 1989·Acta diabetologica latina·J B GarciaJ C Basabe
Aug 21, 2010·Life Sciences·Min J KwonJeong H Park

Related Concepts

Calcium
Chromium
Dose-Response Relationship, Drug
Glucose, (beta-D)-Isomer
Glycolysis
Novolin
Islets of Langerhans
Leucine
Potassium
Monospan

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