Chromium malate alleviates high-glucose and insulin resistance in L6 skeletal muscle cells by regulating glucose uptake and insulin sensitivity signaling pathways

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Wei-Wei FengXiang-Yang Wu

Abstract

Previous study revealed that chromium malate improved the regulation of fasting blood glucose and insulin resistance in type 2 diabetic rats. In this study, the effect of chromium malate on anti-high-glucose and improve insulin resistance activities in L6 skeletal muscle cells with insulin resistance and its acting mechanism were investigated. Chromium malate showed direct anti-high-glucose activity in vitro. The glucose levels had a significant downward trend compared to chromium trichloride. Compared with model group, chromium malate could significantly promote the secretion levels of GLUT-4, Akt, Irs-1, PPARγ, PI3K and p38-MAPK, promote AMPKβ1 phosphorylation, and reduced the level of p-Irs-1 in L6 cells with insulin resistance. And the relate mRNA expression of chromium malate was significantly increased. Chromium malate is more effective at improving the related proteins and mRNA expression than those of chromium trichloride and chromium picolinate. Pretreatment with the specific p38MAPK inhibitor completely inhibited the GLUT-4 and Irs-1 proteins and mRNA expression induced by the chromium malate when compared with model group, but GLUT-4 and Irs-1 proteins and mRNA expression was partially inhibited after inhibiting p38M...Continue Reading

References

Apr 10, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Maria A AnderssonBjörn E Hellman
May 22, 2007·Free Radical Biology & Medicine·Isabelle HiningerRichard A Anderson
Apr 24, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Xueqin MaoYujing Tang
Aug 21, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Fawzia M RefaieWael H Aboul Nour
Dec 17, 2010·Biological Trace Element Research·Xiang-Yang WuLiu-Qing Yang
Sep 20, 2011·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Fang LiLiuqing Yang
Oct 1, 2011·The Journal of Nutritional Biochemistry·Mahmood S MozaffariWorku Abebe
Aug 9, 2013·Human & Experimental Toxicology·Y BaiT Chai
Mar 19, 2014·Diabetes Research and Clinical Practice·L GuariguataJ E Shaw
Sep 13, 2014·Molecular Nutrition & Food Research·Nicholas P GannonRoger A Vaughan
Jan 13, 2015·Journal of Ethnopharmacology·Yixuan LiuLiyuan Duan
May 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shih-Yu LeeTsu-Chung Chang
Aug 26, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ana N PaivaMaria das G Almeida
May 11, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Qi ZhouQing-Hua Liu
Aug 9, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Song WangPing Shi
Dec 18, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Fabiane Ferreira MartinsCarlos Alberto Mandarim-de-Lacerda
Jan 6, 2017·Diabetology & Metabolic Syndrome·Ramona Al-ZoairyAndreas Niederwanger
Feb 16, 2017·Current Hypertension Reports·Sunil K PanchalLindsay Brown
Mar 16, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S NagarjunBaburao N Chandakavathe
Mar 30, 2017·International Journal of Biological Macromolecules·Yukun JiaoChunyan Yan
Apr 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Priyanka MokashiNancy Pandita
Dec 19, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Der Jiun OoiMaznah Ismail

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Citations

Oct 3, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·John B Vincent
Jan 20, 2021·Clinical and Experimental Pharmacology & Physiology·Fateme KooshkiBahram Pourghassem Gargari
Jun 8, 2021·Archives of Biochemistry and Biophysics·Kazuhiko NishimuraHiroshi Nakagawa

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Methods Mentioned

BETA
protein assay
electrophoresis
PCR
Assay

Software Mentioned

Quantity One
SPSS

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