Chromium supplementation enhances insulin signalling in skeletal muscle of obese KK/HlJ diabetic mice

Diabetes, Obesity & Metabolism
W-Y ChenF C Mao

Abstract

Chromium is an essential nutrient required for glucose and lipid metabolism. Laboratory and clinical evidences indicate that chromium supplementation may improve insulin sensitivity by enhancing intracellular signalling. Considerable evidence suggests that serine phosphorylation of insulin receptor substrate 1 (IRS1) at 307 residue (IRS1-Ser307) inhibits insulin signalling and results in peripheral insulin resistance. Therefore, we investigated whether chromium-associated insulin action was mediated by modulation of IRS1-Ser307 phosphorylation. Male KK/HlJ mice (genetically obese and insulin resistant) were supplemented daily with chromium-containing milk powder or placebo for 7 weeks. In analysing functionally characterized insulin resistance, the changes of blood biochemicals, inflammatory factors and insulin signalling molecules in skeletal muscle were analysed. Using KK mice model, we demonstrated that daily supplementation of trivalent chromium-containing milk powder reduced serum levels of glucose, insulin and triglycerides, and improved glucose and insulin tolerance. Mechanistic study showed that chromium supplementation activated postreceptor insulin signalling such as increasing IRS1, IRS1 tyrosine phosphorylation, p85...Continue Reading

References

Nov 1, 1991·Clinical and Experimental Immunology·M G CavalloR Thorpe
Apr 1, 1987·Metabolism: Clinical and Experimental·R A AndersonJ J Canary
Apr 1, 1967·Diabetologia·M Nakamura, K Yamada
May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Feb 15, 1996·The Journal of Clinical Investigation·M SaghizadehP A Kern
Apr 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·G S Mahdi
Dec 5, 1998·Biological Trace Element Research·W DingQ Qian
Dec 16, 1998·Journal of the American College of Nutrition·R A Anderson
Jan 23, 1999·European Journal of Endocrinology·J SutoK Sekikawa
Aug 17, 1999·Annual Review of Nutrition·H C Lukaski
Aug 23, 2000·The Journal of Clinical Investigation·H N Ginsberg
Aug 23, 2000·The Journal of Clinical Investigation·B B Kahn, J S Flier
Oct 19, 2000·The New England Journal of Medicine·D J Rader
Dec 22, 2000·The American Journal of Clinical Nutrition·J E GuntonA McElduff
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·P A KernG Ranganathan
Jun 29, 2002·Science·Claire R WestonRoger J Davis
Nov 6, 2002·The Journal of Biological Chemistry·Yong Hee LeeMorris F White
Nov 26, 2002·Nature·Jiro HirosumiGökhan S Hotamisligil
Jul 25, 2003·The Journal of Physiology·Vsevolod Y PolotskyChristopher P O'Donnell
Sep 28, 2004·Nature Medicine·Hideaki KanetoMasatsugu Hori
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
Jul 14, 2005·Annual Review of Nutrition·U SinghI Jialal
Oct 1, 2005·Journal of Thrombosis and Haemostasis : JTH·P F BodaryD T Eitzman
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
Sep 30, 2006·Annals of Medicine·Craig S StumpJames R Sowers
Nov 7, 2006·Neurochemistry International·Su-Lan LiaoChun-Jung Chen
Dec 21, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yongzhong WeiJames R Sowers

❮ Previous
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Citations

Apr 29, 2010·Current Diabetes Reports·Zhong Q Wang, William T Cefalu
May 5, 2011·Nutrition & Metabolism·Mehmet TuzcuKazim Sahin
Mar 20, 2012·The Journal of Nutritional Biochemistry·Yinan HuaNair Sreejayan
Sep 10, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Alexey A TinkovAlexandr A Nikonorov
Mar 19, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Po-Wen ChenFrank Chiahung Mao
Jul 17, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ewelina Król, Zbigniew Krejpcio
Jun 2, 2010·Biochemical and Biophysical Research Communications·Wen-Ying ChenFrank Chiahung Mao
May 21, 2014·Journal of Diabetes Investigation·Chang LinFrank Chiahung Mao
Jun 2, 2012·Journal of Diabetes·Bhuvaneshwari SundaramRajat Sandhir
Jun 5, 2015·Biological Trace Element Research·Tsung-Sheng ChenFrank Chiahung Mao
Sep 24, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ewelina Król, Zbigniew Krejpcio
Apr 6, 2017·Biological Trace Element Research·Ljubomir JovanovićDanijela Kirovski
Jan 31, 2017·Journal of Animal Physiology and Animal Nutrition·M PantelićD Kirovski
Oct 1, 2009·Diabetes/metabolism Research and Reviews
Jun 6, 2009·Basic & Clinical Pharmacology & Toxicology·Geng-Ruei ChangFrank Chiahung Mao
Jul 14, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Aviva Levina, Peter A Lay
Dec 14, 2011·International Journal of Food Sciences and Nutrition·Peck Loo Kiew, Mashitah Mat Don
Oct 20, 2015·Metabolic Brain Disease·Wen-Ying ChenChun-Jung Chen
Feb 6, 2019·International Journal of Molecular Sciences·Ching-Ping YangWen-Ying Chen
Jul 23, 2019·Clinical and Experimental Pharmacology & Physiology·Fardin MoradiBahram Pourghassem Gargari
Jul 31, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omid AsbaghiAlavi Naeini Amirmansour

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