Chromium treatment of depression

The International Journal of Neuropsychopharmacology
Malcolm N McLeod, Robert N. Golden

Abstract

Eight patients with refractory mood disorders received chromium supplements and described dramatic improvements in their symptoms and functioning. In several instances, single-blind trials confirmed specificity of response to chromium. Side-effects were rare and mild, and most commonly included enhanced dreaming and mild psychomotor activation. To our knowledge, this is the first case series describing the response to chromium monotherapy. The putative antidepressant effects of chromium could be accounted for by enhancement of insulin utilization and related increases in tryptophan availability in the central nervous system, and/or by chromium's effects on norepinephrine release.

Citations

Feb 1, 2003·Biological Psychiatry·Jonathan R T DavidsonMalcolm N McLeod
Aug 22, 2008·Diabetes Technology & Therapeutics·Stephen D AntonDonald A Williamson
Jul 20, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Vivek Kumar DubeyRazia Khanam
Dec 3, 2005·Psychiatry Research·Verena HenkelUlrich Hegerl
Oct 12, 2005·Mutation Research·Ramadevi GudiRichard H C San
Nov 19, 2013·Journal of Dietary Supplements·Kimberly A BrownleyMalcolm N McLeod
Jun 30, 2006·Expert Opinion on Pharmacotherapy·Roger S McIntyreSidney H Kennedy
Jun 29, 2010·Journal of Affective Disorders·Nadia IovienoDavid Mischoulon
Nov 28, 2014·Drugs·Kimberly A BrownleyCynthia M Bulik
Jan 17, 2007·Journal of Clinical Psychopharmacology·Benedikt L AmannHeinz Grunze
Feb 5, 2019·Biological Trace Element Research·Anna PiotrowskaGabriel Nowak
Oct 25, 2013·Food & Function·Luana M ManossoAna Lúcia S Rodrigues
Nov 14, 2012·Psychotherapy and Psychosomatics·Louisa G SylviaAndrew A Nierenberg
Oct 24, 2020·Journal of Water and Health·Caitlyn C WhitakerGregory S Gorman

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