Chromium(III) complexes inhibit transcription factors binding to DNA and associated gene expression

Toxicology
Natesan S Raja, Balachandran Unni Nair

Abstract

Role of chromium(III) in biological systems is controversial and no significant conclusions can be arrived with the available data. Chromium(VI) enters in to the cell readily and gets reduced to form stable chromium(III) complexes. Chromium(III) complexes react slowly and were considered non-toxic. Recent studies suggest that chromium(III) indeed produce damage to cellular organelle, DNA and proteins and can be lethal to organisms and their offspring. Several chromium(III) complexes synthesized are shown to interact with DNA and bring changes in the conformation of DNA and proteins. In this work, effects of these interactions in the vital process like transcription have been studied. Three Cr(III) complexes with varied ligand environment, ionic character and charge have been chosen for the study to evaluate their ability to interrupt the binding of two different transcription factors Sp1 and TFIID, with their consensus sequences and interruption of the transcription process. Of the three complexes tested [Cr(salen)(H(2)O)(2)](+) is the most efficient inhibitor of transcription factors-DNA (TF-DNA) complex formation and transcription. Inhibition of TF-DNA complex formation and transcription by this complex is concentration-depen...Continue Reading

Citations

Jul 19, 2011·Metallomics : Integrated Biometal Science·Erika MitchellBibudhendra Sarkar
Sep 21, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Duraisamy Senthil RajaKaruppannan Natarajan
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Mar 4, 2011·Angewandte Chemie·Ping WangChi-Ming Che
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Jun 10, 2017·Chemical Reviews·Wenhu ZhouJuewen Liu
Jun 5, 2021·Toxicology and Industrial Health·Dalia Abdel Moneim KheirallahAmal Mohamed Shouman
Jul 19, 2021·Seminars in Cancer Biology·Andrew VonHandorfAlvaro Puga

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