Chromium(III)-induced structural changes and self-assembly of collagen

Biochemical and Biophysical Research Communications
R GayatriT Ramasami

Abstract

Rat tail tendon (RTT) collagen has been reacted with a homologous series of chromium(III) complexes viz., (H2O)(4)Cr(OH)(2)Cr(H2O)(4+)(4) 1 (dimer), Cr(3)(OH)(4)(H2O)(5+)(9) 2 (trimer), and Cr(4)(OH)(4)(O2)(H2O)(4+)(12) 3 (tetramer), and the structural alterations brought about by these complexes have been investigated through atomic force microscopy (AFM) and circular dichroism (CD) studies. Examination of Cr(III)-treated tendons using AFM revealed changes in the D-periodicity of collagen, which may arise due to differences in the topological distribution of various Cr(III) complexes. Evidence for organisation of monomeric collagen into quarter staggered fibrils in the presence of Cr(III) dimer, 1, has been obtained. The quaternary structural changes induced by chromium in the protein have been correlated to the conformational changes of collagen in the absence of denaturation.

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Citations

Apr 11, 2012·International Journal of Molecular Sciences·Ramamourthy GopalYoonkyung Park
Jun 5, 2012·Acta Biomaterialia·Young Jae ParkDae Won Moon
Sep 1, 2009·Journal of Photochemistry and Photobiology. B, Biology·R UshaT Ramasami
Apr 8, 2006·Journal of Structural Biology·David A CisnerosDaniel J Muller
Aug 1, 2015·Biochemistry·Avanish S ParmarVikas Nanda
Aug 7, 2014·Scientific Reports·Marimuthu NidhinBalachandran Unni Nair
Sep 27, 2005·International Journal of Biological Macromolecules·B MadhanT Ramasami
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