Chromium(III) propionate complex supplementation improves carbohydrate metabolism in insulin-resistance rat model

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Ewelina Król, Zbigniew Krejpcio

Abstract

The purpose of this study was to evaluate the antidiabetic potential and safety of the chromium(III) propionate complex (CrProp) in insulin resistance induced by a high-fructose diet in rats. The experiment was carried out on 32 nine-week old male Wistar rats divided into 4 groups of 8 rats each. Animals were fed at libitum: the control diet (AIN-93M), and high-fructose diets (HF) containing various levels of Cr(III) given as CrProp (1 mg Cr kg(-1) diet (HF) and supplemented with 10 mg Cr kg(-1) diet (HFCr10), or 50 mg Cr kg(-1) diet (HFCr50), equal to approx. 0.1, 1 and 5 mg kg(-1) body mass per day) for 8 weeks. It was found that supplemental CrProp improved carbohydrate metabolism indices (decreasing serum insulin levels and insulin resistance indices HOMA-IR and HOMA-B, while increasing insulin sensitivity index QUICKI). Supplemental CrProp did not affect overall nutritional indices, blood morphology, most of the toxicity indices, blood glucose and lipids levels, while it increased kidney Cr level (HFCr50), normalized decreased liver Cu concentrations, and decreased kidney Fe and Cu levels (HFCr50). Supplemental CrProp administered at 10- and 50-fold doses of the basal dietary Cr level has a significant antidiabetic effect ...Continue Reading

References

Feb 1, 1989·Journal of the American College of Nutrition·R Marks-KaufmanG F Barbato
Jan 27, 1999·The Journal of Clinical Endocrinology and Metabolism·M A BanerjiH E Lebovitz
Jun 16, 1999·Chemical Research in Toxicology·J K SpeetjensS A Woski
Aug 13, 1999·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·B W MorrisT A Gray
Jul 29, 2000·Accounts of Chemical Research·J B Vincent
Jul 27, 2001·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·B J ClodfelderJ B Vincent
Aug 31, 2002·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yanjie SunJohn B Vincent
Nov 5, 2003·Journal of Cellular and Molecular Medicine·Urmila A Shinde, R K Goyal
Feb 28, 2004·Journal of Inorganic Biochemistry·Buffie J ClodfelderJohn B Vincent
Apr 10, 2004·Biological Trace Element Research·Buffie J ClodfelderJohn B Vincent
Apr 28, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J I MannUNKNOWN Diabetes and Nutrition Study Group (DNSG) of the European Association
Apr 28, 2005·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Buffie J Clodfelder, John B Vincent
Jun 13, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·M M BaileyJ B Vincent
Nov 25, 2006·Molecular and Cellular Biochemistry·Meliha Sengezer InceliRefiye Yanardag
Jan 24, 2007·Life Sciences·Panchamoorthy Rajasekar, Carani Venkatraman Anuradha
Mar 17, 2007·Journal of Toxicology and Environmental Health. Part a·Agnieszka Scibior, Halina Zaporowska
May 22, 2007·Free Radical Biology & Medicine·Isabelle HiningerRichard A Anderson
Nov 14, 2007·Metabolism: Clinical and Experimental·Zhong Q WangWilliam T Cefalu
Dec 17, 2008·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Hannah E Bartlett, Frank Eperjesi
Feb 7, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·H YadavF Marotta
Mar 26, 2009·Biological Trace Element Research·Qiang Xu, Jianyou Guo
May 8, 2009·Metabolic Syndrome and Related Disorders·Nayyar IqbalPhilippe O Szapary
Aug 5, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Halina Staniek, Zbigniew Krejpcio
Sep 23, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Halina StaniekZbigniew Krejpcio
Dec 29, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Halina StaniekKatarzyna Iwanik
Jan 19, 2011·Biological Trace Element Research·Halina StaniekDaria Wieczorek

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Citations

Dec 17, 2010·Biological Trace Element Research·Xiang-Yang WuLiu-Qing Yang
Jan 15, 2014·Biological Trace Element Research·Ewelina KrólKatarzyna Iwanik
Apr 23, 2014·Biological Trace Element Research·Anna PreschaHalina Grajeta
Jul 22, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·John B Vincent
Sep 20, 2011·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Fang LiLiuqing Yang
Sep 24, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ewelina Król, Zbigniew Krejpcio
Mar 1, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fang LiLiuqing Yang
Jun 18, 2016·Biological Trace Element Research·Alexey A TinkovAnatoly V Skalny
Sep 26, 2016·Journal of Inorganic Biochemistry·Bin LiuBinsheng Yang
May 3, 2013·Chemical Communications : Chem Comm·Nicolas P E Barry, Peter J Sadler
Dec 30, 2017·International Journal of Molecular Medicine·Qian ZhangXiaojing Wang
Jan 20, 2021·Clinical and Experimental Pharmacology & Physiology·Fateme KooshkiBahram Pourghassem Gargari
Sep 21, 2011·Journal of Inorganic Biochemistry·Harry G PreussNicholas V Perricone

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