Chromoanagenesis: cataclysms behind complex chromosomal rearrangements

Molecular Cytogenetics
Franck Pellestor

Abstract

During the last decade, genome sequencing projects in cancer genomes as well as in patients with congenital diseases and healthy individuals have led to the identification of new types of massive chromosomal rearrangements arising during single chaotic cellular events. These unanticipated catastrophic phenomenon are termed chromothripsis, chromoanasynthesis and chromoplexis., and are grouped under the name of "chromoanagenesis". For each process, several specific features have been described, allowing each phenomenon to be distinguished from each other and to understand its mechanism of formation and to better understand its aetiology. Thus, chromothripsis derives from chromosome shattering followed by the random restitching of chromosomal fragments with low copy-number change whereas chromoanasynthesis results from erroneous DNA replication of a chromosome through serial fork stalling and template switching with variable copy-number gains, and chromoplexy refers to the occurrence of multiple inter-and intra-chromosomal translocations and deletions with little or no copy-number alterations in prostate cancer. Cumulating data and experimental models have shown that chromothripsis and chromoanasynthesis may essentially result fro...Continue Reading

References

Dec 3, 1999·Heredity·L H RiesebergR K Wayne
Jan 26, 2000·Nature·J Britton-DavidianM da Luz Mathias
Dec 1, 2000·Nature·B VogelsteinA J Levine
Apr 3, 2001·Nature Reviews. Genetics·T Cremer, C Cremer
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·D GisselssonN Mandahl
May 27, 2003·Nature Cell Biology·Michael LisbyRodney Rothstein
Dec 10, 2003·Oncogene·Jordan S Fridman, Scott W Lowe
Oct 18, 2005·Current Opinion in Cell Biology·Dana Branzei, Marco Foiani
Jan 19, 2006·The Journal of Cell Biology·Jill M BrownVeronica J Buckle
Feb 27, 2007·Molecular Biology and Evolution·Anton Crombach, Paulien Hogeweg
Oct 16, 2007·Current Opinion in Genetics & Development·Giacomo Cavalli
Jan 30, 2008·Nature Reviews. Genetics·Andrés Aguilera, Belén Gómez-González
Mar 29, 2008·Current Opinion in Genetics & Development·Jamy C Peng, Gary H Karpen
Apr 18, 2009·Journal of Human Genetics·Hiroki KurahashiTamae Ohye
May 1, 2009·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Andrea ImlePeter Friedl
Jun 30, 2009·Trends in Genetics : TIG·Feng ZhangJames R Lupski
Mar 10, 2010·Genome Research·Louise HarewoodAlexandre Reymond
Mar 24, 2010·Mutation Research·Mariona TerradasAnna Genescà
Feb 26, 2011·Human Molecular Genetics·Wigard P KloostermanEdwin Cuppen
Feb 26, 2011·Nature·Jose M C Tubio, Xavier Estivill
May 5, 2011·Cell Cycle·Giovanni Ciavarra, Eldad Zacksenhaus
Jan 20, 2012·Nature·Karen CrastaDavid Pellman
Jan 24, 2012·Cell·Christopher A Maher, Richard K Wilson
Feb 14, 2012·Journal of Cell Science·P M KrawczykJ A Aten
Feb 22, 2012·Cell Research·Yun HuangQinghua Shi
Mar 1, 2012·Current Opinion in Genetics & Development·Martin F ArltThomas W Glover
Mar 24, 2012·Current Opinion in Genetics & Development·Pengfei LiuJames R Lupski
Apr 10, 2012·Nature Cell Biology·Judith Miné-Hattab, Rodney Rothstein
Apr 13, 2012·Critical Reviews in Biochemistry and Molecular Biology·Carolyn M George, Eric Alani
Sep 14, 2012·Nature Reviews. Cancer·Josep V FormentStephen P Jackson
Nov 17, 2012·Developmental Cell·Mathew J K Jones, Prasad V Jallepalli
Mar 13, 2013·Current Opinion in Cell Biology·Wigard P Kloosterman, Edwin Cuppen
Mar 19, 2013·Cell·Jan O Korbel, Peter J Campbell

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Citations

Mar 4, 2020·American Journal of Medical Genetics. Part a·Morasha Plesser DuvdevaniTamar Harel
Aug 26, 2020·American Journal of Medical Genetics. Part a·Sarah AnzickPhilip M Murphy
Sep 18, 2020·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Alejandro D Bolzán
Jan 8, 2020·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Parithi Balachandran, Christine R Beck
Mar 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Vikas YadavJoseph Heitman
Feb 6, 2020·Molecular Cytogenetics·Franck Pellestor, Vincent Gatinois
Aug 20, 2019·Trends in Genetics : TIG·Luca Comai, Ek Han Tan
Feb 11, 2021·Genome Biology and Evolution·Itay Mayrose, Martin A Lysak
Nov 12, 2020·International Journal of Molecular Sciences·Ivan Y IourovSergei I Kutsev
Jan 16, 2021·The Urologic Clinics of North America·Sujit S NairAshutosh K Tewari
Mar 1, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yongchang ZhangNong Yang
Oct 12, 2020·Bulletin du cancer·Julie LemaireNicolas Pottier
May 15, 2021·American Journal of Medical Genetics. Part a·Darine VillelaCarla Rosenberg
Apr 15, 2021·Journal of Experimental Botany·Tejas ThondehaalmathRavi Maruthachalam
Aug 28, 2021·Cancers·Roni Rasnic, Michal Linial
Aug 30, 2021·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Alejandro D Bolzán
Nov 21, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Farhad KosariAaron S Mansfield

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