Chromoendoscopy and magnification endoscopy for diagnosing esophageal cancer and dysplasia

Thoracic Surgery Clinics
Michael J Connor, Prateek Sharma

Abstract

Based on preliminary reports, the use of chromoendoscopy and magnification endoscopy appears to be a valuable adjunct to standard endoscopy for the detection and classification of metaplastic and dysplastic lesions of the esophagus. Ideally, the use of this technique would enable the endoscopist to rule in or out the presence of intestinal metaplasia and dysplastic/cancerous epithelium by obtaining only a minimal number of targeted biopsy specimens--or potentially taking no biopsies at all, which could transform upper endoscopy into a much more effective screening and surveillance tool. There are several problems with the use of chromoendoscopy and magnification endoscopy in the esophagus. This technique is operator-dependent (ie, dependent on the skill and experience of the endoscopist). Studies reporting the accuracy of chromoendoscopy remain mixed, especially for Barrett's esophagus and dysplasia, which is likely explained by differences in techniques and materials used in the investigations. Staining within the esophagus is often patchy and uneven. Poor spraying technique can exaggerate irregular uptake by the mucosa. There is a high false-positive rate when staining gastric-type epithelium or in the setting of inflammation...Continue Reading

Citations

Nov 20, 2009·HNO·N Stasche
Nov 26, 2008·Gastroenterology Clinics of North America·Savio C Reddymasu, Prateek Sharma
Jul 30, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Dongsuk ShinRebecca R Richards-Kortum
Apr 11, 2012·The American Journal of Gastroenterology·Vani J A Konda, Irving Waxman
Jan 9, 2013·Nature Reviews. Gastroenterology & Hepatology·Michael SchweigertHubert J Stein
Oct 12, 2018·Current Gastroenterology Reports·Mansoureh Mkarimi, Hiroshi Mashimo
Jun 24, 2010·Current Opinion in Gastroenterology·Irving Waxman, Vani J A Konda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Related Papers

Gastrointestinal Endoscopy Clinics of North America
Elena I Sidorenko, Prateek Sharma
Journal of Clinical Gastroenterology
Hiroshi MashimoRaj K Goyal
Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
R E Sampliner
© 2021 Meta ULC. All rights reserved