Chromoendoscopy and magnifying endoscopy in patients with gastroesophageal reflux disease. Useful or negligible?

Digestive Diseases
R KiesslichPeter R Galle

Abstract

Gastroesophageal reflux disease (GERD) is common in the Western world. Upper endoscopy is needed to characterize the disease. Barrett's esophagus as a complication of GERD is an established precancerous condition which can lead to adenocarcinoma in the distal esophagus. This review summarizes recent advances in the endoscopic characterization of Barrett's esophagus using magnification endoscopy and chromoendoscopy. Methylene blue, indigo carmine and acetic acid are commonly used dyes to facilitate diagnosis of Barrett's esophagus. Methylene blue is absorbed in the specialized columnar epithelium, which is pathognomonic for Barrett's esophagus. Indigo carmine and acetic acid are used as contrast stains to highlight the surface architecture. Currently, different dyes are used in conjunction with magnifying endoscopes to characterize specific surface patterns of Barrett's epithelium. However, the current proposed classifications are too complex relative to their clinical value. Nevertheless, simplification of these systems will occur over time with increased use of magnifying chromoendoscopy. The value of magnifying chromoendoscopy for clinical practice is not determined yet and currently under investigation. However, these techni...Continue Reading

Citations

Jul 4, 2006·Gastrointestinal Endoscopy·Massimo Conio
Mar 26, 2008·Anesthesiology·Laszlo VutskitsDenis R Morel
Aug 16, 2005·Journal of Korean Medical Science·Inn-Se KimJeung-Il Kim
Nov 22, 2005·Journal of Surgical Oncology·E J Kuipers, J Haringsma
Apr 12, 2007·Journal of Clinical Gastroenterology·Irvin M ModlinStuart J Spechler
Mar 27, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Tsuneo Oyama

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