PMID: 6962622Jan 1, 1982Paper

Chromogenic peptide substrate assays in patients with multiple trauma

Acta Chirurgica Scandinavica. Supplementum
P KierulfJ Vaage

Abstract

Daily monitoring of the plasma proteolytic enzyme systems i.e. the coagulation, the fibrinolytic and the kallikrein-kinin system in multitraumatized patients with chromogenic substrate assays disclosed significant differences in the levels of Prekallikrein, Hageman Factor, Antithrombin-III, Prothrombin in survivors (N = 9) and fatal cases (N = 6) during the first week after admission. Since chromogenic peptide substrate assays are simple, cheap and easily automated, close monitoring of critical care patients may be rewarding.

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