Chromogranin A and cortisol at intraoperative repeated noxious stimuli: Surgical stress in a dog model

SAGE Open Medicine
Odd V HöglundMats Stridsberg

Abstract

Biomarkers representing sympathetic tone and the surgical stress response are measured to objectively evaluate surgical techniques and anaesthetic protocols. If a part of the intraoperative procedure is repeated on the contralateral organ, one animal may potentially serve as its own control and, if so, may minimize the problem of individual differences of the stress response to anaesthesia and surgery. This study aimed to investigate the use of chromogranin A for measurement of the intraoperative sympathetic tone. Additional aims were to investigate chromogranin A and cortisol as indicators of the intraoperative surgical stress response caused by repeated noxious stimuli in dogs subjected to ovariohysterectomy and thereby to investigate the possibility of one dog serving as its own control. Experiments were carried out on 10 dogs subjected to ovariohysterectomy. Perioperative blood samples (0-6) were collected after premedication, immediately before induction of anaesthesia (0), after induction of anaesthesia and before incision (1), before (2) and after (3) removal of the first ovary, after a 15-min pause before removal of the second ovary (4), after removal of the second ovary (5) and after closing the abdomen (6). Plasma chr...Continue Reading

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Citations

Mar 23, 2017·BMC Research Notes·Thanikul SrithunyaratAnn Pettersson
Jan 5, 2017·Acta Veterinaria Scandinavica·Thanikul SrithunyaratAnn Pettersson
Nov 20, 2016·Acta Veterinaria Scandinavica·Odd Viking HöglundKatja Höglund
Aug 25, 2017·American Journal of Veterinary Research·Kristen M FizzanoTodd M Archer
Mar 30, 2021·Veterinary World·I Hernández-AvalosA Domínguez-Oliva
Jan 20, 2020·Research in Veterinary Science·Stefanie HoffroggeReinhard Mischke

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SAS

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