Chromogranin A is a reliable biomarker for gastroenteropancreatic neuroendocrine tumors in an Asian population of patients

Neuroendocrinology
Wen-Chi ChouChien-Feng Sun

Abstract

To evaluate the significance of plasma chromogranin A (CgA) levels in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NET) in terms of disease status and treatment responses. Forty-four GEP-NET patients comprising 15 disease-free patients and 29 patients with active disease, as well as 26 healthy participants were enrolled in this study between April 2010 and April 2011. Clinicopathological factors were collected and serial plasma CgA levels were measured. Plasma CgA levels were significantly higher in GEP-NET patients with active disease than in disease-free patients (p = 0.011) or healthy participants (p = 0.001). No difference in CgA levels was observed in terms of primary tumor location, tumor grade, and functional status in patients with active disease. CgA values at 94 U/l distinguished healthy individuals or disease-free patients from patients with active disease. Sensitivity and specificity rates were 86 and 88%, respectively. CgA levels at 110 U/l differentiated patients without recurrence from those with recurrence, with a sensitivity rate of 100% and a specificity rate of 80%. Patients (5/5, 100%) with stable disease and who showed partial response after treatment had a more than 20% decrease in CgA l...Continue Reading

References

Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Natori, W B Huttner
Jul 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E T JansonK Oberg
Feb 24, 2001·European Journal of Gastroenterology & Hepatology·P TomassettiL Gullo
Aug 28, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MrsićM Gosev
Jan 5, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P TomassettiR Corinaldesi
Feb 6, 2003·Cancer·Irvin M ModlinMark Kidd
Mar 21, 2003·The New England Journal of Medicine·Laurent TaupenotDaniel T O'Connor
May 13, 2003·The Journal of Endocrinology·M StridsbergE T Janson
Jul 11, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M CimitanL De Apollonia
Apr 24, 2004·Clinical Endocrinology·D NeharF Borson-Chazot
May 22, 2004·Annals of the New York Academy of Sciences·Günter KlöppelPhilipp U Heitz
May 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Davide CampanaPaola Tomassetti
Jul 20, 2007·Endocrine-related Cancer·Maria Chiara ZatelliUNKNOWN Italian CromaNet Working Group
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoDouglas B Evans
Sep 4, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·G C NikouE Mallas
Nov 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoBertram Wiedenmann
Jul 14, 2010·The Medical Journal of Australia·Irvin M ModlinMark Kidd

❮ Previous
Next ❯

Citations

Dec 2, 2015·Experimental and Therapeutic Medicine·Zhiqiang WangRui Liang
Mar 18, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Moonjin KimSeung Tae Kim
Jan 1, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Birsen YucelZekiye Hasbek
Dec 20, 2017·Reviews in Endocrine & Metabolic Disorders·Christian FottnerMatthias M Weber
May 23, 2019·Endocrine-related Cancer·Meng JiChenghao Shao
Jul 1, 2013·Frontline Gastroenterology·Mohid Shakil Khan, Martyn E Caplin
Aug 31, 2018·Nature Reviews. Endocrinology·Johannes HoflandWouter W de Herder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición
José Ángel Díaz Pérez, Maria Currás Freixes
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Thomas WalterC Lombard-Bohas
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Davide CampanaPaola Tomassetti
© 2022 Meta ULC. All rights reserved