Chromophobe renal cell carcinoma. Pathologic, ultrastructural, immunohistochemical, cytofluorometric and cytogenetic findings

Pathology, Research and Practice
L Morell-QuadrenyA Llombart-Bosch

Abstract

A case of chromophobe renal cell carcinoma is reported in a 73 year-old man. Light microscopically, the tumor was composed of polygonal cells with a slightly eosinophilic and a fine reticular pattern, and a reaction of the cytoplasm with Hale's acid iron colloid. Ultrastructural analysis showed membranous microvesicles within the tumor cells, with degenerated mitochondria. Immunohistochemical profile against intermediate filaments was positive to cytokeratin 18 and negative against vimentin. Flow cytometry and cytogenetics revealed a predominant hypertriploid population. Few cases have been published with flow cytometry and cytogenetic findings. We report a new case.

References

Jan 1, 1985·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·W ThoenesH J Rumpelt
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·W ThoenesM Müller
Jan 1, 1993·Histopathology·G Kovacs

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Citations

Mar 29, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·J BertrandJ Domergue
Dec 16, 1998·Lancet·N J Vogelzang, W M Stadler
Sep 28, 2014·Biochemical and Biophysical Research Communications·Fandong MengYouhong Jiang
Sep 18, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N G GrimesH Z Malik
May 17, 2003·Clinical Therapeutics·S James Matthews, Christopher McCoy
Mar 7, 2002·Critical Reviews in Oncology/hematology·C M L van Herpen, P H M De Mulder
Jul 10, 2003·Critical Reviews in Oncology/hematology·Robert J Motzer
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M SchulerW E Aulitzky
Feb 26, 2013·Cancer Treatment Reviews·Sumanta K Pal, David I Quinn
Jul 23, 1998·Auris, Nasus, Larynx·T TomitaM Mukai
Jul 2, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ryu KanzakiKen Kodama
Aug 13, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Christian StrongJean-Valery C E Coumans
Aug 5, 1998·Cancer Genetics and Cytogenetics·T DijkhuizenB de Jong
Feb 14, 1998·Cancer Genetics and Cytogenetics·P Dal CinH Van den Berghe
May 9, 2002·Cancer Genetics and Cytogenetics·Danielle BodmerAd Geurts van Kessel
Dec 12, 2002·Urologic Oncology·Vassiliki ZolotaChrisoula Scopa
Sep 29, 2000·Urologic Oncology·J Vuky, R J Motzer
May 15, 2001·BJU International·J Stebbing, M Gore
Apr 23, 2002·BJU International·Chloe P MacaulayA Bishop
Jul 31, 2012·Polski przeglad chirurgiczny·Aneta L ZygulskaKatarzyna Krzesiwo
Jun 7, 2005·Journal of Pediatric Surgery·Ibrahim OtgünAkgün Hiçsönmez
Mar 26, 2015·Seminars in Diagnostic Pathology·Stewart Fleming
Dec 10, 1998·Annals of Diagnostic Pathology·M MichalM Ludvíková
Oct 5, 2001·International Journal of Surgical Pathology·O HesP Miculka
Jul 31, 2007·Pathology, Research and Practice·Pavel DundrJan Dvorácek

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