Chromosomal aberrations and microsatellite instability of malignant peripheral nerve sheath tumors: a study of 10 tumors from nine patients

Cancer Genetics and Cytogenetics
Chikashi KobayashiMasazumi Tsuneyoshi

Abstract

Malignant peripheral nerve sheath tumor (MPNST) is an uncommon soft tissue neoplasm with a poor prognosis, occurring sporadically or associated with neurofibromatosis type 1 (NF1); however, the histogenesis of MPNST remains unclear, especially in sporadic tumors. There are two major forms of genomic instability in human cancer: chromosomal instability (CIN) and microsatellite instability (MSI). An inverse relationship has recently been demonstrated between CIN and MSI in colorectal cancers. CIN and MSI are suggested to be individual pathways, which are involved in the pathogenesis and which may lead to specific clinical and pathological characteristics. To elucidate the chromosomal aberration as a consequence of CIN and MSI status of MPNST, we karyotyped 10 MPNSTs from nine patients, and examined the MSI of seven microsatellite markers using high-resolution fluorescence microsatellite analysis; 2 out of 10 cases (20%) had normal karyotypes, and 8 out of 10 cases (80%) revealed structural and numerical chromosomal aberrations. Three of the 10 cases (30%) showed near triploidy. The most frequent aberration was -22 (40%), followed by +2, +14, -13, -17, and -18 (30% each). An MSI-low status was observed in 30% of cases; the remaini...Continue Reading

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Citations

Oct 21, 2014·Case Reports in Pathology·Taissir OmarAwatef Draz
Dec 25, 2009·Radiation and Environmental Biophysics·Christian Streffer
Nov 27, 2015·Acta neurochirurgica·Mohamed A ElsherifRachel Y Miest
Mar 18, 2008·Revue neurologique·R TekayaM Montacer Kchir
Aug 20, 2009·Genes, Chromosomes & Cancer·Domenico TrombettaClelia Tiziana Storlazzi
Jul 1, 2008·Expert Opinion on Medical Diagnostics·D E Reuss, A von Deimling
Jun 29, 2013·Human Pathology·Makoto EndoYoshinao Oda
Mar 24, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chikashi KobayashiMasazumi Tsuneyoshi
Mar 14, 2007·Current Opinion in Neurology·Ming-Jen Lee, Dennis A Stephenson
Jul 10, 2020·Neuro-oncology Advances·Alexander PemovDavid T Miller
Dec 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Makoto EndoYoshinao Oda
Jan 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Makoto EndoYoshinao Oda

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