Chromosomal Aberrations Associated with Sequential Steps of the Metastatic Cascade in Colorectal Cancer Patients

Clinical Chemistry
Simon A JoosseKlaus Pantel

Abstract

Genomic information can help to identify colorectal tumors with high and low metastatic potential, thereby improving prediction of benefit of local and/or systemic treatment. Here we investigated chromosomal aberrations in relation to the different stages of the metastatic cascade: dissemination of tumor cells into the mesenteric vein, metastatic outgrowth in the liver, intravasation of the peripheral blood circulation, and development of further distant metastasis. Peripheral and mesenteric blood from colorectal cancer patients (n = 72) were investigated for circulating tumor cells, and DNA extracted from their primary tumors was subjected to array comparative genomic hybridization profiling. The results were validated with an independent set of primary colorectal tumors (n = 53) by quantitative reverse transcription PCR. Mesenteric intravasation and liver metastasis were correlated with losses of chromosomes 16p (72%), 16q (27%), and 19 (54%), gain along 1q31 (45%) and 20q (60%), tumor cell infiltration into the peripheral blood circulation, and further distant metastasis with gain of chromosome 8q (59%) and 12 (47%, P < 0.01). Chromosome 12 gain was associated with poor overall survival in the initial (2.8 vs >7 years) and v...Continue Reading

References

Sep 1, 1993·Journal of the National Cancer Institute·K PantelG Riethmüller
Jun 2, 2004·Nature Reviews. Cancer·Klaus Pantel, Ruud H Brakenhoff
Aug 16, 2008·Breast Cancer Research and Treatment·Simon A JoossePetra M Nederlof
Feb 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michaela WrageHarriet Wikman
Feb 10, 2010·Current Treatment Options in Oncology·Benjamin P Negin, Steven J Cohen
Apr 13, 2010·Oncogene·A LièvreP Laurent-Puig
Jul 9, 2010·Breast Cancer Research and Treatment·Simon A JoossePetra M Nederlof
Mar 3, 2011·International Journal of Cancer. Journal International Du Cancer·Robert R Langley, Isaiah J Fidler
Mar 21, 2012·Breast Cancer Research : BCR·Harriet WikmanKlaus Pantel
Dec 29, 2012·Cancer Research·Simon A Joosse, Klaus Pantel
May 23, 2013·Clinical Chemistry·Eric DenèveCatherine Alix-Panabières
Jan 17, 2015·Cancer Research·Laure CayrefourcqCatherine Alix-Panabières
Mar 5, 2016·Cancer Metastasis Reviews·Simon A Joosse, Klaus Pantel

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Citations

Jun 20, 2019·Molecular Oncology·Etienne BuscailCatherine Alix-Panabières
Jul 16, 2020·EMBO Molecular Medicine·Claudia KochKlaus Pantel
Aug 29, 2019·Nature Reviews. Cancer·Laura Keller, Klaus Pantel
Jun 3, 2020·Seminars in Cancer Biology·María González-GonzálezAlberto Orfao
Apr 4, 2021·Cancer Discovery·Catherine Alix-Panabières, Klaus Pantel
Aug 31, 2021·The EMBO Journal·Roberto VendraminCharles Swanton
Oct 9, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Mariola Monika GolasBjoern Sander
Nov 13, 2021·Clinical & Experimental Metastasis·Stanley P LeongMarlys Witte

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