PMID: 11914143Mar 27, 2002Paper

Chromosomal aberrations in benign and malignant bilharzia-associated bladder lesions analyzed by comparative genomic hybridization

BMC Cancer
Imad Fadl-ElmulaSverre Heim

Abstract

Bilharzia-associated bladder cancer (BAC) is a major health problem in countries where urinary schistosomiasis is endemic. Characterization of the genetic alterations in this cancer might enhance our understanding of the pathogenic mechanisms of the disease but, in contrast to nonbilharzia bladder cancer, BAC has rarely been the object of such scrutiny. In the present study, we aimed to characterize chromosomal imbalances in benign and malignant post-bilharzial lesions, and to determine whether their unique etiology yields a distinct cytogenetic profile as compared to chemically induced bladder tumors. DNAs from 20 archival paraffin-embedded post-bilharzial bladder lesions (6 benign and 14 malignant) obtained from Sudanese patients (12 males and 8 females) with a history of urinary bilharziasis were investigated for chromosomal imbalances using comparative genomic hybridization (CGH). Subsequent FISH analysis with pericentromeric probes was performed on paraffin sections of the same cases to confirm the CGH results. Seven of the 20 lesions (6 carcinomas and one granuloma) showed chromosomal imbalances varying from 1 to 6 changes. The most common chromosomal imbalances detected were losses of 1p21-31, 8p21-pter, and 9p and gain ...Continue Reading

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Citations

Nov 20, 2012·Journal of the Egyptian National Cancer Institute·Mohamed S Zaghloul
Sep 7, 2004·Expert Review of Molecular Diagnostics·Kathleen DorritieThomas Ried
Jun 22, 2012·Expert Review of Anticancer Therapy·Mohamed S Zaghloul, Iman Gouda
Jun 25, 2015·Expert Review of Anti-infective Therapy·Sanaa EissaNada O E Essawy
Dec 1, 2020·Journal of the Egyptian National Cancer Institute·Mohamed S ZaghloulBrian C Baumann
Mar 5, 2021·Frontiers in Oncology·Solomon O RotimiBodour Salhia
Dec 4, 2003·European Urology·Philipp Dahm, Jürgen E Gschwend

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