May 1, 1993

Chromosomal aberrations in peripheral lymphocytes of nurses and physicians handling antineoplastic drugs

Mutation Research
T GrummtG Schott

Abstract

The frequencies of structural chromosome aberrations of persons occupationally exposed to antineoplastic drugs without adequate protection were measured in peripheral blood lymphocytes of 106 persons from five oncological units and in an adequate control population. The observed chromosomal aberration frequencies were 3.3 +/- 0.1 aberrations per 100 cells in the exposed group and 0.6 +/- 0.1 aberrations per 100 cells in the controls. Chromosomal aberration frequencies were not correlated with age, duration of exposure and smoking habits. The results stress the necessity to protect hospital staff against the potential risk related to the handling of antineoplastic drugs.

  • References20
  • Citations17

Mentioned in this Paper

Antineoplastic Agents
Lymphoid Cells
Occupational Diseases
Autosome Abnormalities
Substance-Related Disorders
Mutagenesis Process
Cigar smoker

About this Paper

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