PMID: 6166857Mar 1, 1981Paper

Chromosomal aberrations in the peripheral lymphocytes of cancer patients treated with high-energy electrons and bleomycin

Mutation Research
G ObeD Göbel

Abstract

5 patients with inoperable bronchogenic carcinomas on a weekly therapy with a low dose of bleomycin (BL) plus irradiation with high-energy electrons, were analysed cytogenetically by cultivating peripheral lymphocytes taken immediately before the BL treatments and some hours before the irradiations. For the induction of dicentric chromosomes, linear dose-effect relationships were found: 3 of the patients responded with similar dose-effect relationships. The other 2 were different: they were not comparable with those 3 or with each other. These results were unexpected because all 5 patients received similar types of treatment.

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A D D'Andrea, W A Haseltine
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M TakeshitaH Ohtsubo
Jan 1, 1979·Nucleic Acids Research·A R Lehmann, S Stevens
Oct 1, 1972·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S J Jorgensen
Jun 1, 1974·The British Journal of Radiology·N M BleehenP R Twentyman

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