Jul 1, 1986

Chromosomal aberrations, SCE and urine mutagenicity in workers occupationally exposed to cytostatic drugs

Mutation Research
H PohlováP Rössner


The genetic risk run by workers occupationally exposed to chemicals, including the newly developed cytostatics, was assessed in large chemical laboratories. The exposed group comprising 38 people consisted of chemists, laboratory assistants and pilot plant workers. The average rate of aberrant cells in peripheral blood lymphocytes (AB.C). was 3.9% and the value of break/cell ratio was 0.046. The group of matched controls (N = 18) was found to have 1.5% of AB.C. and 0.020 breaks/cell. In the exposed group, there were, on average, 8.94 SCEs/cell, and in controls, 5.81. Urine mutagenicity tests on Salmonella typhimurium tester strain TA98 revealed a significant increase of activity in 23 (64%) out of 36 urine samples tested as compared to the control group (N = 19) with 4 (21%) positive urine samples. Strain TA100 showed only a weak response to urine mutagens.

Mentioned in this Paper

Antineoplastic Agents
Drug Formulation Process
Peripheral Blood
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Mutagenicity Tests
Sister Chromatid Exchange
Lymphoid Cells
Cytostatic Agents

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