Chromosomal abnormalities and dyserythropoiesis in the preleukaemic phase of multiple myeloma

British Journal of Haematology
M B Dahlke, P C Nowell

Abstract

Two patients with multiple myeloma and one patient with a plasma-cytoma are reported in whom acute leukaemia developed following long-term treatment with melphalan. Each patient had a complete remission of the plasma cell disorder during which time the bone marrow was moderately to severely hypoplastic. The end of the clinical remission was heralded by a dyserythropoietic anaemia which persisted several months before the emergence of the terminal acute leukaemia. Marked chromosomal abnormalities were observed in marrow cells during the dyserythropoietic phase.

References

Sep 8, 1973·Lancet·W Van HoveL Demeulenaere
Jun 1, 1974·Lancet·D Dubovsky, P Jacobs
Nov 19, 1970·The New England Journal of Medicine·R A KyleE D Bayrd

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