Chromosomal abnormalities and the morphology of mouse sperm heads

Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie
Andrew J WyrobekW R Bruce

Abstract

In the mouse, numerous mutagens, teratogens and carcinogens have been shown to induce marked elevations in the fraction of sperm with head shape abnormalities. Since carcinogens and teratogens may act by causing genetic damage, a likely explanation of these results is that the sperm abnormalities are also caused by genetic damage. There are two more or less distinct classes of genetic damage, chromosomal aberrations and point mutations. In this paper, we provide evidence, that in general, chromosomal aberrations are not responsible for causing abnormally shaped sperm. Chromosomal aberrations could have caused abnormal sperm morphology in a number of ways. One possibility was that the mere presence of a translocated chromosome within the germ cell led to the malformation of the sperm head. A second possibility was that chromosomal imbalance, i.e., aneuploidy, duplications or deficiencies, within the spermatid or haploid cells caused abnormalities in shape. We tested these hypotheses by measuring the level of abnormally shaped sperm in mice homozygous and heterozygous for 24 various reciprocal and Robertsonian translocations. The diploid cells of these mice are known to be chromosomally balanced, containing translocated chromosom...Continue Reading

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Citations

Oct 20, 2006·Human Reproduction·M DavissonM A Handel
Dec 1, 1983·Journal of Dairy Science·B L Gledhill
Jan 1, 1984·Annals of the New York Academy of Sciences·B L Gledhill
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Jan 1, 1983·Mutation Research·A P Hugenholtz, W R Bruce
Jul 14, 2007·Journal of Ethnopharmacology·Muibat B AmidaOlufunmilayo O Adeyemi

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