Chromosomal abnormalities in products of conception of first-trimester miscarriages detected by conventional cytogenetic analysis: a review of 1000 cases

Journal of Assisted Reproduction and Genetics
Larysa Y PylypValery D Zukin

Abstract

The purpose of this study is to perform a retrospective analysis of types and frequencies of chromosomal abnormalities detected by conventional cytogenetic studies in first-trimester miscarriages after spontaneous conception and IVF. Standard cytogenetic analysis of GTG-banded chromosomes obtained from products of conception (POCs): semi-direct and short-term cultured chorionic villi or long-term cultured fetal mesodermal cells. 50.1% of first-trimester miscarriages in the studied group had chromosomal abnormalities: 59.7% of trisomies, 22% of poliploidies, 7.5% of monosomies, 7% of unbalanced structural abnormalities, and 3.8% of multiple aneuploidies. An increase in the frequency of chromosomally abnormal miscarriages was observed in the group of women above 40 when compared to groups of women under 35 (P < 0.05). No difference in frequencies and types of chromosomal abnormalities in POCs of miscarriages after ICSI and spontaneous conception was observed. Approximately, 50% of first-trimester miscarriages have chromosomal abnormalities which can be detected by conventional cytogenetic analysis. The presence of chromosomal abnormality may explain the cause of miscarriage, improving the reproductive counseling and planning.

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Citations

May 12, 2019·Biology of Reproduction·Svetlana A Yatsenko, Aleksandar Rajkovic
May 23, 2019·Frontiers in Genetics·Alla S KoltsovaVladislav S Baranov
Jun 2, 2020·Journal of Obstetrics and Gynaecology of India·R K Bhatt, M Agarwal
May 7, 2021·Obstetrics and Gynecology·Margot van RielKatrien Janssens
Dec 4, 2020·Fertility and Sterility·Mauro CozzolinoJose Bellver
May 12, 2021·Journal of Cellular and Molecular Medicine·Meiying CaiHailong Huang
May 14, 2021·Human Reproduction Update·Geerke M EggenhuizenRobert Jan Galjaard
Aug 12, 2021·PloS One·Seyyedeh Neda KazemiMohammad Javad Nasiri

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