Chromosomal abnormalities in starved and marginally malnourished rats and in utero upon rehabilitation

Experientia
V Alu, P B Murthy

Abstract

The effects of starvation and marginal malnutrition (MN) on the lymphocytes of rats were evaluated by chromosomal analysis before and after rehabilitation. The effect of parental starvation or malnutrition on chromosomal aberrations in the foetus was also studied. Wistar rats, 30-35 days old, were starved for 5 days or fed a minimally restricted or a severely restricted diet for three weeks. At the end of the period of starvation or malnutrition, lymphocytes were isolated and chromosomal analysis was performed. Starved and severely restricted rats showed significantly higher mean chromosomal aberrations than the controls. These aberrations returned to a normal level when the experimental groups were rehabilitated for a month, indicating that the damage was transient. A chromosomal aberration study done on foetal cells from rehabilitated rats which had previously been starved or fed a severely restricted diet showed significantly increased values, indicating that some damage was permanent. A low number of implantations was also recorded in these experimental groups. These observations clearly indicate that young animals exposed to conditions like starvation or chronic malnutrition are prone to permanent damage of the genetic sys...Continue Reading

References

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Citations

Jul 6, 2014·Toxicology and Applied Pharmacology·Melanie GuérardLutz Müller
Sep 30, 2014·Biological Trace Element Research·Gisel PadulaAnalía I Seoane
Apr 6, 2004·Environmental and Molecular Mutagenesis·Rocío OrtizEdith Cortés
Nov 29, 2011·Mutation Research·Elsa Cervantes-RíosLeonor Rodríguez-Cruz
Mar 21, 2016·Mutation Research·M Monserrat Pacheco-MartínezRocío Ortiz-Muñiz
Jan 1, 1997·Environmental and Molecular Mutagenesis·R OrtizM Betancourt

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