Chromosomal abnormalities in two bladder carcinomas with secondary squamous cell differentiation

Cancer Genetics and Cytogenetics
I Fadl-ElmulaS Heim

Abstract

Two secondary squamous cell carcinomas of the bladder (i.e., tumors that originated from primary transitional cell carcinomas) were examined cytogenetically. Both tumors showed complex karyotypes with many of the same aberrations that have formerly been described in transitional cell carcinomas. Monosomy 9, trisomy 7, and rearrangements of chromosomes 3, 8, 10, 13, and 17 were common to both tumors. Among other changes that have been implicated in bladder carcinogenesis, an isochromosome for 5p was seen in one tumor and loss of 11p material in the other. Our findings indicate that secondary squamous cell carcinomas of the bladder are karyotypically indistinguishable from advanced transitional cell carcinomas of the same organ. The putative genetic changes that steer the differentiation of the neoplastic epithelium in the direction of squamous cells thus remain unknown.

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Citations

Dec 22, 1999·Cancer Genetics and Cytogenetics·I Fadl-ElmulaS Heim
Feb 20, 2014·Der Urologe. Ausg. A·S RauschT Kälble
Jun 25, 2015·Expert Review of Anti-infective Therapy·Sanaa EissaNada O E Essawy
Jul 25, 2015·Urologic Oncology·Jay D Raman, Syed M Jafri
Jul 14, 2007·Expert Review of Anticancer Therapy·Peter C BlackColin P N Dinney
Feb 9, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Yunguang LiuBo Xu
Feb 7, 2007·Urology·Hassan Abol-EneinAdrienne J K Carmack
Mar 28, 2008·Urologic Oncology·Peter C BlackColin P N Dinney

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