Chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011-2015

Italian Journal of Pediatrics
Xiao-Hui ZhangJian Xu

Abstract

Recently, the prevalence of chromosomal abnormalities (CA) increased as the increasing proportion of mothers with advanced age. We aimed to explore the prevalence of CA in relation to maternal age and perinatal features. A retrospective study was performed based on provincial birth defects surveillance data. The relative risk (RR) and 95% confidence interval (CI) were used to calculate maternal age-specific rates of CA. Socio-demographic characteristics of mothers and perinatal features were listed. The total prevalence of CA was 6.38 per 10,000 births, which increased per 10,000 births linearly from 4.02 in 2011 to 9.13 in 2015 (x 2line-trend =52.69, p < 0.001). During this period, the prevalence for CA per 10,000 births among women over 35 years old increased from 15.34 in 2011 to 33.82 in 2015 (x 2line-trend =115121.6, p < 0.001). The RR for overall CA, trisomy 21(T21), trisomy 18(T18) and others in mothers 35 years or older were 6.64 (95% CI 5.55 ~ 7.93), 6.83 (95% CI 5.63 ~ 8.30), 4.06 (95% CI 2.09 ~ 7.90) and 7.54 (95% CI 4.02 ~ 14.11) respectively in comparison to mothers aged 25-29 years old. The stillbirths rate for total CA was 76.45%. T21 and T18 were strongly associated with multiple anomalies, especially congenital...Continue Reading

References

Nov 8, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yuan-yuan GongXing-wei Wu
Apr 14, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Claire IrvingNicholas D Embleton
Sep 10, 2014·Journal of Epidemiology·Elhadi H AburawiYousef M Abdulrazzaq
Sep 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Jan Pieter MarchalA S Paul van Trotsenburg
Jun 23, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Deepa Balachandran NairMargery Morgan
Sep 9, 2015·American Journal of Medical Genetics. Part a·Anna SpringettJoan K Morris
Oct 30, 2015·Italian Journal of Pediatrics·Tatjana GliveticMaida Seferovic Saric
Dec 15, 2015·American Journal of Medical Genetics. Part a·Robert E MeyerUNKNOWN National Birth Defects Prevention Network
Jan 15, 2016·Archives of Disease in Childhood. Fetal and Neonatal Edition·Angela K Lucas-HeraldRuth McGowan
Mar 29, 2016·Journal of Intellectual Disability Research : JIDR·M AlexanderO Khwaja
May 18, 2016·British Journal of Biomedical Science·Jiansheng ZhuIhtisham Bukhari
Jun 28, 2016·Taiwanese Journal of Obstetrics & Gynecology·Yuning ZhuZhengyou Miao
Jul 28, 2016·JAMA : the Journal of the American Medical Association·Katherine E NelsonAstrid Guttmann

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