Chromosomal alterations in pure nonneoplastic breast lesions: implications for breast cancer progression

Annals of Surgical Oncology
Rachel E EllsworthCraig D Shriver

Abstract

Columnar cell lesions (CCL) and atypical ductal hyperplasia (ADH) frequently coexist and share molecular changes with in situ and invasive components, suggesting that CCL and ADH may be precursors to breast cancer. These conclusions are largely based on studies examining CCL and/or ADH from patients diagnosed with more advanced disease. We assessed allelic imbalance (AI) in pure CCL or ADH specimens to characterize molecular changes in nonneoplastic breast lesions. DNA samples were obtained from laser-microdissected pure CCL (n = 42) or ADH (n = 31). AI was assessed at 26 chromosomal regions commonly altered in breast cancer. Data were analyzed using Fisher's exact and Student's t-tests using a cutoff of P < 0.05. The average AI frequency was 6.2% in CCL and 6.1% in ADH; approximately 33% of nonneoplastic lesions had no detectable genetic changes. Levels of AI in CCL and ADH were significantly (P < 0.0001) lower than observed in either low- or high-grade ductal carcinoma in situ (DCIS) lesions. Genetic changes characteristic of in situ and invasive disease, especially on chromosomes 16q and 17p, were infrequent in pure nonneoplastic lesions. Pure CCL and ADH lesions demonstrate lower levels of genetic alterations than DCIS, inv...Continue Reading

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Citations

Oct 30, 2012·Breast Cancer Research and Treatment·Anoek H J Verschuur-MaesPaul J van Diest
Mar 31, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Megan L TroxellRobert B West
Mar 8, 2019·The Journal of Pathology·Tanjina KaderKylie L Gorringe
Jun 29, 2011·Expert Review of Anticancer Therapy·Jennifer GassDon S Dizon
Jul 7, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mirthe de BoerPaul J van Diest
May 4, 2018·Breast Cancer Research : BCR·Tanjina KaderKylie L Gorringe

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