Chromosomal assignment of human endogenous retrovirus K (HERV-K) env open reading frames

Cytogenetics and Cell Genetics
Jens MayerN Mueller-Lantzsch

Abstract

The haploid human genome contains at least one human endogenous retrovirus K (HERV-K) env gene displaying an open reading frame, as evidenced by the high antibody titers against HERV-K Env in germ cell tumor patients at the time of tumor detection. However, the chromosomal assignment of an intact HERV-K env sequence is complicated by the existence of 25-30 HERV-K copies per haploid human genome. Recently, we reported the application of the protein truncation test (PTT) to chromosomally assign HERV-K gag open reading frames. Here, we set out to determine the chromosomal distribution of full-length HERV-K env genes. As demonstrated by somatic hybrid mapping and the PTT, HERV-K env open reading frames were found on human chromosomes 7, 19, and Y. By sequencing chromosome-specific HERV-K env subregions, we assigned two recently reported intact HERV-K sequences on human chromosomes 7 and 19, respectively. Chromosomes 7 and 19 and the Y are furthermore candidates for harboring a putative completely intact HERV-K locus.

Citations

Feb 2, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E D Sverdlov
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·H KarlssonR H Yolken
Jan 12, 2001·AIDS Research and Human Retroviruses·M PadowE M Towler
Feb 23, 2000·FEBS Letters·A BoeseN Mueller-Lantzsch
Feb 8, 2005·Journal of Molecular Evolution·Catriona Macfarlane, Peter Simmonds
Aug 12, 2005·Cytogenetic and Genome Research·J Mayer, E Meese
Mar 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Cécile VoissetDavid J Griffiths
Dec 25, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Bernd KroneJohn M Grange

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