PMID: 58947Apr 1, 1976

Chromosomal assignment of the HL-A common antigenic determinants in man-mouse somatic cell hybrids

Journal of Immunogenetics
M SmithD Pressman

Abstract

In the study presented here, man-mouse somatic cell hybrid clones were examined by means of radioimmunoassays for the presence of both beta2-microglobulin (beta2m) and the HL-A xenoantigenic determinant. In addition, the clones were examined for their karyotype and the expression of enzymes with known chromosomal assignments. The results obtained indicate that the gene coding for the HL-A xenoantigenic determinant is carred on chromosome 6. The data obtained provides a direct demonstration that the gene coding for beta2m segregates independently of that coding for the alloantigenic polypeptide chain of the HL-A molecule, and that the gene coding for beta2m is carried on chromosome 15.

References

Jul 1, 1976·European Journal of Immunology·L OstbergP A Peterson
Dec 1, 1973·The Journal of Experimental Medicine·H M GreyJ L Strominger
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonJ B Lindblom
Jul 26, 1969·Nature·M NabholzW F Bodmer
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H van SomerenO B Zaalberg
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·P CresswellJ L Strominger
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·K NakamuroD Pressman
Jan 1, 1973·Biochemical Genetics·E A NicholsF H Ruddle
Oct 1, 1973·Annals of Human Genetics·D A HopkinsonH Harris
May 26, 1971·Nature: New Biology·L U LammF Kissmeyer-Nielsen
May 1, 1971·Annals of Human Genetics·Y H EdwardsH Harris
Jul 22, 1967·Nature·W H Lewis, H Harris

Citations

May 1, 1980·Journal of Toxicology and Environmental Health·Y UsamiG A Gellin
Nov 1, 1976·European Journal of Immunology·J Ayres, P Cresswell

Related Concepts

Antigenic Specificity
Beta(1)CA Globulin
Beta-2 Microglobulin
Genome Mapping
Chromosomes, Human,13-15
Chromosomes, Human,6-12
Clone Cells
SD Antigens
HLA Antigens
Hybrid Cells

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.