PMID: 58947Apr 1, 1976

Chromosomal assignment of the HL-A common antigenic determinants in man-mouse somatic cell hybrids

Journal of Immunogenetics
M SmithD Pressman


In the study presented here, man-mouse somatic cell hybrid clones were examined by means of radioimmunoassays for the presence of both beta2-microglobulin (beta2m) and the HL-A xenoantigenic determinant. In addition, the clones were examined for their karyotype and the expression of enzymes with known chromosomal assignments. The results obtained indicate that the gene coding for the HL-A xenoantigenic determinant is carred on chromosome 6. The data obtained provides a direct demonstration that the gene coding for beta2m segregates independently of that coding for the alloantigenic polypeptide chain of the HL-A molecule, and that the gene coding for beta2m is carried on chromosome 15.


Jul 1, 1976·European Journal of Immunology·L OstbergP A Peterson
Dec 1, 1973·The Journal of Experimental Medicine·H M GreyJ L Strominger
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonJ B Lindblom
Jul 26, 1969·Nature·M NabholzW F Bodmer
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H van SomerenO B Zaalberg
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·P CresswellJ L Strominger
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·K NakamuroD Pressman
Jan 1, 1973·Biochemical Genetics·E A NicholsF H Ruddle
Oct 1, 1973·Annals of Human Genetics·D A HopkinsonH Harris
May 26, 1971·Nature: New Biology·L U LammF Kissmeyer-Nielsen
May 1, 1971·Annals of Human Genetics·Y H EdwardsH Harris
Jul 22, 1967·Nature·W H Lewis, H Harris


May 1, 1980·Journal of Toxicology and Environmental Health·Y UsamiG A Gellin
Nov 1, 1976·European Journal of Immunology·J Ayres, P Cresswell

Related Concepts

Antigenic Specificity
Beta(1)CA Globulin
Beta-2 Microglobulin
Genome Mapping
Chromosomes, Human,13-15
Chromosomes, Human,6-12
Clone Cells
SD Antigens
HLA Antigens
Hybrid Cells

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