Aug 1, 1975

Chromosomal basis of the merozygosity in a partially deploid mutant of Pneumococcus

Genetics
M L Ledbetter, R D Hotchkiss

Abstract

A sulfonamide-resistant mutant of pneumococcus, sulr-c, displays a genetic instability, regularly segregating to wild type. DNA extracts of derivatives of the strain possess transforming activities for both the mutant and wild-type alleles, establishing that the strain is a partial diploid. The linkage of sulr-c to strr-61, a stable chromosomal marker, was established, thus defining a chromosomal locus for sulr-c. DNA isolated from sulr-c cells transforms two mutant recipient strains at the same low efficiency as it does a wild-type recipient, although the mutant property of these strains makes them capable of integrating classical "low-efficiency" donor markers equally as efficiently as "high efficiency" markers. Hence sulr-c must have a different basis for its low efficiency than do classical low efficiency point mutations. We suggest that the DNA in the region of the sulr-c mutation has a structural abnormality which leads both to its frequent segregation during growth and its difficulty in efficiently mediating genetic transformation.

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Mentioned in this Paper

Antibiotic Resistance, Microbial
Transformation, Genetic
Genome Mapping
Haploid Cell
Sulfonamides
Chromosomes, Bacterial
DNA Replication
Diploid Cell
Streptococcus pneumoniae
Crosses, Genetic

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