Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer

Oncotarget
Irina V KovtunGeorge Vasmatzis

Abstract

Massive genomic rearrangements, a result of single catastrophic event termed chromothrispsis or chromosomal catastrophe, have been identified in a variety of human cancers. In a few cancer types, chromothripsis was found to be associated with poor prognosis. We performed mate-pair sequencing and analysis of structural rearrangements in 132 prostate cancer cases which included clinically insignificant Gleason score 6 tumors, clinically significant tumors of higher grade (7+) and high grade prostatic intraepithelial neoplasia. Chromothripsis was observed at least 30 per cent of the samples across different grades. Surprisingly, it was frequently observed in clinically insignificant Gleason score 6 tumors, indicating that chromothripsis does not define more aggressive phenotype. The degree of chromothripsis did not increase significantly in tumors of advanced grades and did not appear to contribute to tumor progression. Our data showed that distribution of chromothriptic rearrangements differed from that of fragile sites but correlated with the size of chromosomes. We also provided evidence that rearrangements resulting from chromothripsis were present in the cells of neighboring Gleason patterns of the same tumor. Our data sugges...Continue Reading

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Citations

Jul 5, 2017·Nature Reviews. Urology·Mindy Kim Graham, Alan Meeker
Jun 22, 2017·Expert Review of Molecular Diagnostics·Minke SmitsJack A Schalken
Nov 28, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stephen J MurphyJohn C Cheville
Feb 24, 2018·Leukemia·Maria Chiara FontanaGiovanni Martinelli
Nov 10, 2018·Genes, Chromosomes & Cancer·Tilmann BochtlerAlwin Krämer
Jan 3, 2021·The Journal of Molecular Diagnostics : JMD·Stephen MurphyGeorge Vasmatzis
Jan 16, 2021·The Urologic Clinics of North America·Sujit S NairAshutosh K Tewari
Nov 5, 2020·Genomics·Stephen J MurphyMarie Christine Aubry

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Methods Mentioned

BETA
PCR
Laser Capture Microdissection
chromosomal aberrations

Software Mentioned

R script

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