Chromosomal features of Escherichia coli serotype O2:K2, an avian pathogenic E. coli

Standards in Genomic Sciences
Steffen L JørgensenRikke H Olsen

Abstract

Escherichia coli causing infection outside the gastrointestinal system are referred to as extra-intestinal pathogenic E. coli. Avian pathogenic E. coli is a subgroup of extra-intestinal pathogenic E. coli and infections due to avian pathogenic E. coli have major impact on poultry production economy and welfare worldwide. An almost defining characteristic of avian pathogenic E. coli is the carriage of plasmids, which may encode virulence factors and antibiotic resistance determinates. For the same reason, plasmids of avian pathogenic E. coli have been intensively studied. However, genes encoded by the chromosome may also be important for disease manifestation and antimicrobial resistance. For the E. coli strain APEC_O2 the plasmids have been sequenced and analyzed in several studies, and E. coli APEC_O2 may therefore serve as a reference strain in future studies. Here we describe the chromosomal features of E. coli APEC_O2. E. coli APEC_O2 is a sequence type ST135, has a chromosome of 4,908,820 bp (plasmid removed), comprising 4672 protein-coding genes, 110 RNA genes, and 156 pseudogenes, with an average G + C content of 50.69%. We identified 82 insertion sequences as well as 4672 protein coding sequences, 12 predicated genomic ...Continue Reading

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Datasets Mentioned

BETA
CP001855
.1
SAMN04503534
AY545598.5
AY214164.3

Software Mentioned

Mauve
Genome Genome Distance Calculator
RAST
ResFinder
QUAST
CLC Genomic Workbench
MEGA
GeneMark
RNAmmer
NGS Cell

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