PMID: 9421365Jan 8, 1998Paper

Chromosomal fragility in the cancer-prone disease xeroderma pigmentosum preferentially involves bands relevant for cutaneous carcinogenesis

International Journal of Cancer. Journal International Du Cancer
A LanzaM Stefanini

Abstract

Spontaneous and folate-induced chromosomal fragility was analyzed in peripheral blood lymphocytes from 6 patients affected by the cancer-prone disease xeroderma pigmentosum (XP), from the parents of 4 of the patients, and from 12 normal subjects. All XP patients were defective in nucleotide-excision repair; 4 belonged to group C and 1 each to groups A and D. A tendency toward increased spontaneous chromosomal fragility was observed in the XP family members, and lesions indicating substantial chromosomal damage, which were not observed in any healthy donors, were frequently found. The spontaneous lesion sites in lymphocytes from homozygous and heterozygous carriers of XP defects appeared to be significantly associated with those observed in normal skin fibroblasts from the same subjects. These XP spontaneous fragility sites showed a statistically significant association with the rearrangement breakpoints reported in skin pre-tumoral and tumoral lesions from normal and unrelated XP donors. Under conditions of folate deprivation, the chromosomal fragility level, the pattern and the frequency of expression of fragile sites in XP patients and in their parents were similar to normal. However, XP patients generally showed a higher sus...Continue Reading

References

Jan 1, 1992·Cancer Genetics and Cytogenetics·O I SokovaB P Kopnin
Jan 1, 1985·Cytogenetics and Cell Genetics·R BergerG R Sutherland
Dec 1, 1994·Genes, Chromosomes & Cancer·F MertensN Mandahl
Oct 1, 1995·Mutation Research·V A Bohr, R M Anson
Oct 1, 1994·Cancer Genetics and Cytogenetics·Y Y OzisikA A Sandberg
Sep 1, 1994·Nature Genetics·C J HussussianN C Dracopoli
Apr 1, 1994·Cancer Genetics and Cytogenetics·F MertensN Mandahl
Jul 1, 1993·Nature Genetics·P S MeltzerJ M Trent

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Citations

Sep 17, 2004·International Journal of Radiation Biology·I R Radford
Dec 22, 2005·Journal of the National Cancer Institute·Li-E WangQingyi Wei

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