PMID: 2494448Mar 1, 1989Paper

Chromosomal hypersensitivity in mutant MCN-151 mouse cells exposed to mitomycin C

Mutation Research
F Rosselli, E Moustacchi

Abstract

After exposure to mitomycin C, the mouse lymphoma cell mutant MCN-151, previously shown to be sensitive to the toxic effect of the drug, demonstrates higher frequencies of chromatid-type aberrations and of aberrant cells in comparison to L5178Y cells. At any given dose of mitomycin C, the frequencies of chromosomal aberrations increased with time reaching a plateau in both cell strains, with the mutant in all cases being more sensitive than normal cells.

Citations

Nov 1, 1990·Somatic Cell and Molecular Genetics·M Z ZdzienickaJ W Simons

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