Chromosomal imbalances in Barrett's adenocarcinoma and the metaplasia-dysplasia-carcinoma sequence

The American Journal of Pathology
A WalchM Werner

Abstract

To characterize cytogenetic alterations found in Barrett's adenocarcinoma (BA) and, more importantly, its premalignant stages, we studied chromosomal imbalances in various lesions in the histologically proposed metaplasia-dysplasia-carcinoma sequence using comparative genomic hybridization (CGH). Using 30 esophageal adenocarcinoma resection specimens, we were able to study 30 areas of Barrett's adenocarcinoma and 8 lymph node metastases (LN). In addition, we investigated 25 premalignant lesions adjacent to BA derived from a subset of 14 resection specimens including 11 areas of high grade dysplasia (HGD), 8 areas of low grade dysplasia (LGD), and 6 areas of intestinal metaplasia (IM), which were laser-microdissected and studied with CGH. To validate the CGH findings, fluorescence in situ hybridization analysis on 13 BA with probes specific for HER-2/neu and 20q13.2 were performed. The chromosomal alterations most often identified in BA were: gains on 8q (80%), 20q (60%), 2p, 7p and 10q (47% each), 6p (37%), 15q (33%) and 17q (30%). Losses were observed predominantly on the Y-chromosome (76%), 4q (50%), 5q and 9p (43% each), 18q (40%), 7q (33%) and 14q (30%). High-level amplifications were observed on 8q23-qter, 8p12-pter, 7p11-...Continue Reading

References

Oct 1, 1976·Science·P C Nowell
May 1, 1992·Human Pathology·J E McArdleW Weinstein
Aug 1, 1992·The Annals of Thoracic Surgery·M PeraP C Pairolero
Mar 23, 1991·JAMA : the Journal of the American Medical Association·W J BlotJ F Fraumeni
Aug 1, 1990·Japanese Journal of Cancer Research : Gann·H NakataniM Terada
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y HattoriM Terada
Aug 7, 1986·The New England Journal of Medicine·S J Spechler, R K Goyal
Nov 1, 1986·Somatic Cell and Molecular Genetics·M Fukumoto, I B Roninson
Sep 20, 1995·Journal of the National Cancer Institute·J Sanz-OrtegaM J Merino
May 8, 1993·International Journal of Cancer. Journal International Du Cancer·M al-KasspoolesD G Beer
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·P C GalipeauB J Reid
Sep 1, 1996·Cancer Genetics and Cytogenetics·M B Menke-PluymersA Hagemeijer
Jun 18, 1997·Journal of the National Cancer Institute·L MaoW K Hong
Jul 1, 1997·Seminars in Surgical Oncology·N K AltorkiD S Schrump
Oct 17, 1998·Cancer Genetics and Cytogenetics·D L PersonsR Cherian
May 13, 1999·Nature Genetics·M T BarrettB J Reid
May 18, 1999·The American Journal of Pathology·C A RumpelC A Moskaluk
Jun 23, 1999·Oncogene·C E NesbitE V Prochownik
Aug 7, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Schutte
Aug 7, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C WallrappT M Gress
Oct 21, 1999·Journal of the National Cancer Institute·L BubendorfO P Kallioniemi
Dec 11, 1999·Virchows Archiv : an International Journal of Pathology·M WernerH Höfler
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sandra RauserAxel Walch

❮ Previous
Next ❯

Citations

Jan 17, 2004·World Journal of Surgery·James MuellerManfred Stolte
Apr 20, 2005·Virchows Archiv : an International Journal of Pathology·Ryoji KushimaManfred Stolte
Jun 20, 2002·Cancer Genetics and Cytogenetics·Stéphanie StruskiPascale Cornillet-Lefebvre
Jan 26, 2002·Cancer Letters·Yoshihiro NakakuboHiroyuki Katoh
Jul 27, 2002·Cancer Letters·Xiao Ping HuangMing Rong Wang
Nov 7, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A DriessenUNKNOWN H.P. Belgian Contact Group
Sep 30, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Giulia PaselloDaniela Saggioro
Mar 16, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mona FahmyGary W Falk
Jul 17, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Azita DjalilvandOlivier Kocher
May 29, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paula ChavesJorge Soares
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
May 23, 2009·Current Opinion in Gastroenterology·Yutaka Tomizawa, Kenneth K Wang
Nov 23, 2007·Journal of Gastroenterology and Hepatology·Irene VeghEnrique Moreno-González
Dec 21, 2010·Journal of Gastroenterology and Hepatology·Wayne A PhillipsDavid C Whiteman
May 7, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas G PaulsonBrian J Reid
Feb 14, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William W LockwoodDavid G Beer
Jan 19, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Harry H YoonFrank A Sinicrope
Aug 29, 2013·Nature Reviews. Gastroenterology & Hepatology·Jamie M J WeaverRebecca C Fitzgerald
Jun 30, 2000·Biochemical and Biophysical Research Communications·K IkedaS Inoue
Jun 8, 2001·American Journal of Clinical Pathology·M SarbiaH E Gabbert
Jul 12, 2002·American Journal of Clinical Pathology·Helene GeddertMario Sarbia
May 11, 2004·World Journal of Surgical Oncology·Christine P J CaygillRebecca C Fitzgerald
Jul 24, 2002·Gastroenterology Clinics of North America·Michelle Beilstein, Debra Silberg
Jul 9, 2005·International Journal of Cancer. Journal International Du Cancer·Xiaoli MaJingwu Xie
Oct 31, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·L D WangX S Feng
Jul 21, 2005·International Journal of Cancer. Journal International Du Cancer·Mariska HageHerman van Dekken
Oct 2, 2009·International Journal of Cancer. Journal International Du Cancer·Nikolas H Stoecklein, Christoph A Klein
Jul 9, 2004·The Journal of Veterinary Medical Science·Yasuhiko OkamuraYasuho Taura
Jul 27, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A K WalchM Werner

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