Chromosomal instability and marker chromosome evolution in oral squamous cell carcinoma

Genes, Chromosomes & Cancer
S C ReshmiS M Gollin

Abstract

Squamous cell carcinoma of the head and neck and its subset, oral squamous cell carcinoma (OSCC), arise through a multistep process of genetic alterations as a result of exposure to environmental agents, such as tobacco smoke, alcoholic beverages, and viruses, including human papillomavirus. We and others have shown that the karyotypes of OSCC are near-triploid and contain multiple structural and numerical abnormalities. However, despite a background of clonal chromosomal aberrations, individual cells within a culture express many nonclonal numerical and structural abnormalities, termed chromosomal instability (CIN). To evaluate CIN in oral cancer cells, we isolated clones from two OSCC cell lines and carried out classical cytogenetic analysis, fluorescence in situ hybridization using centromere-specific probes, and spectral karyotyping. We observed variation in chromosome number within clones and between clones of the same cell line. Although similar numbers of centromeric signals for a particular chromosome were present, "homologs" of a chromosome varied structurally from cell to cell (marker chromosome evolution) as documented by classical and spectral karyotyping. In addition to the numerical chromosome variations within a ...Continue Reading

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Citations

Jan 11, 2014·The Journal of Craniofacial Surgery·Ana Luíza Laguardia CantaruttiEliete Neves da Silva Guerra
Dec 2, 2005·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Marga NadalVirginia Nunes
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Dec 23, 2004·Seminars in Cancer Biology·Susanne M Gollin
May 27, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·L MontebugnoliMaria P Foschini
Apr 29, 2016·Genes, Chromosomes & Cancer·Hatem O KasebSusanne M Gollin
Jan 26, 2005·Journal of Dental Research·S C Reshmi, S M Gollin
Jan 7, 2006·Cancer Research·John P WittschiebenRichard D Wood
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer R Grandis
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rudolf ReiterAxel Walch

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