PMID: 16628000Apr 22, 2006Paper

Chromosomal instability, colorectal cancer and taxane resistance

Cell Cycle
Charles SwantonJulian Downward

Abstract

The spindle checkpoint monitors the fidelity of chromosome separation during mitosis. Aberrations in key regulators of this process have been found in human malignancies associated with chromosomal instability (CIN). Important chemotherapeutic agents which alter microtubule dynamics such as paclitaxel and vincristine, prolong spindle checkpoint activation and delay the completion of mitosis. Intriguingly, inhibition of BubR1 or overexpression of Aurora kinase A, spindle checkpoint regulators implicated in CIN, promote resistance to microtubule inhibitors (MTIs) in vitro. Taxanes have failed to demonstrate significant clinical benefit in phase II trials in colorectal cancer (CRC). The high incidence of CIN in this disease, coupled with alterations in spindle checkpoint regulators in vivo, may explain the disappointing results associated with taxane based therapies for CRC. A phase II trial of taxanes in patients with metastatic CIN negative CRC may be indicated.

Citations

Apr 9, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yafang WangDaiming Fan
May 27, 2009·Expert Reviews in Molecular Medicine·Alvin J X LeeCharles Swanton
Feb 24, 2010·Nature Reviews. Clinical Oncology·Madeleine HewishAlan Ashworth
May 8, 2013·Nature Reviews. Clinical Oncology·Roger P A'HernCharles Swanton
May 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Charles SwantonJulian Downward
Dec 21, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Samuel F BakhoumDuane A Compton
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Koen De GeestWilliam E Richards
Dec 14, 2007·Expert Opinion on Therapeutic Targets·Vinay K Singh, Zongchao Jia
Mar 1, 2007·Expert Opinion on Drug Discovery·Nadine DarwicheHala Gali-Muhtasib
Mar 28, 2008·Expert Opinion on Investigational Drugs·Michelle Harrison, Charles Swanton
Dec 15, 2010·Expert Opinion on Investigational Drugs·Branislav Bystricky, Ian Chau
May 9, 2012·Journal of Proteomics·Hee-Young YangTae-Hoon Lee
Oct 10, 2006·Clinical Lung Cancer·Oliver GautschiDavid R Gandara
Jun 12, 2008·Biochimica Et Biophysica Acta·Renske van LeukenRob Wolthuis
Dec 11, 2007·Biochimica Et Biophysica Acta·Barbara T McGroganAmanda McCann
Dec 22, 2009·Molecular BioSystems·Ran Brosh, Varda Rotter
Mar 27, 2013·Journal of Internal Medicine·A SilvestriC Belluco
Dec 9, 2014·Cell Cycle·J Bargiela-IparraguirreI Sánchez-Pérez
May 7, 2015·BMC Cancer·Christine HowFei-Fei Liu
Feb 13, 2016·Journal of Photochemistry and Photobiology. B, Biology·Ajeet K SrivastavRatan Singh Ray
Apr 16, 2009·British Journal of Cancer·C Swanton, C Caldas
Oct 27, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J OvermanS Kopetz
Aug 30, 2017·Journal of Toxicology and Environmental Health. Part a·Eduarda Lopes-CostaAlice A Ramos
Jan 13, 2015·World Journal of Gastroenterology : WJG·Claudia MaletzkiMichael Linnebacher
Jan 1, 2008·Cancer Informatics·Aimee L JacksonPeter S Linsley
Mar 5, 2015·Cell Structure and Function·Yuji NakayamaMitsuo Oshimura
Jul 9, 2014·Oncotarget·Serena GiovinazziAlexander M Ishov
Aug 21, 2020·Journal of Clinical Pathology·Tomohiro SugiyamaKen Sugimoto
Jun 15, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arjen H G ClevenManon van Engeland
Aug 3, 2006·Genes & Development·Renée van Amerongen, Anton Berns

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