Chromosomal localization and partial genomic structure of the human peroxisome proliferator activated receptor-gamma (hPPAR gamma) gene

Biochemical and Biophysical Research Communications
B A BeamerA R Shuldiner

Abstract

We determined the chromosomal localization and partial genomic structure of the coding region of the human PPAR gamma gene (hPPAR gamma), a nuclear receptor important for adipocyte differentiation and function. Sequence analysis and long PCR of human genomic DNA with primers that span putative introns revealed that intron positions and sizes of hPPAR gamma are similar to those previously determined for the mouse PPAR gamma gene[13]. Fluorescent in situ hybridization localized hPPAR gamma to chromosome 3, band 3p25. Radiation hybrid mapping with two independent primer pairs was consistent with hPPAR gamma being within 1.5 Mb of marker D3S1263 on 3p25-p24.2. These sequences of the intron/exon junctions of the 6 coding exons shared by hPPAR gamma 1 and hPPAR gamma 2 will facilitate screening for possible mutations. Furthermore, D3S1263 is a suitable polymorphic marker for linkage analysis to evaluate PPAR gamma's potential contribution to genetic susceptibility to obesity, lipoatrophy, insulin resistance, and diabetes.

References

Aug 1, 1992·Diabetes Care·C A Hofmann, J R Colca
Jan 1, 1995·Molecular and Cellular Biology·P TontonozB M Spiegelman
Sep 1, 1993·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·J L SantosM Díez

❮ Previous
Next ❯

Citations

Nov 20, 2008·Cancer Immunology, Immunotherapy : CII·Tatiana M Garcia-BatesRichard P Phipps
Sep 10, 2008·PPAR Research·Ioannis SainisEvangelos Briasoulis
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tatiana M Garcia-BatesRichard P Phipps
Dec 2, 2015·Schizophrenia Research·Stefanie Malan-MüllerSoraya Seedat
Sep 1, 2005·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·T OmiS Neuenschwander
Aug 2, 2007·Expert Opinion on Therapeutic Targets·Efstathia PapageorgiouMichael Koutsilieris
Jul 30, 2002·Diabetes·Michael Stumvoll, Hans Häring
Apr 4, 2003·Diabetes/metabolism Research and Reviews·Roland RosmondClaude Bouchard
Mar 20, 2003·Current Diabetes Reports·Francesco S Celi, Alan R Shuldiner
Jun 22, 2010·American Journal of Reproductive Immunology : AJRI·Kyu Ri HwangShin Yong Moon
Oct 26, 1999·Endocrine Reviews·B Desvergne, W Wahli
Nov 30, 2006·Pharmacological Reviews·Liliane MichalikWalter Wahli
Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·R A HegeleC M Anderson
Mar 30, 2017·PPAR Research·Melody ChiuTerry D Hinds
Sep 18, 2020·Cancers·Giuseppina AugimeriDaniela Bonofiglio
Jul 18, 2018·International Journal of Molecular Sciences·Patricia CorralesGema Medina-Gómez
Feb 26, 2000·Journal of Medicinal Chemistry·T M WillsonB R Henke
Dec 21, 2005·Biochemical and Biophysical Research Communications·Ulrika EdvardssonJan Oscarsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
B AkpinarE Memişoğlu
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Hidefumi SasakiYoshitaka Fujii
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Stamatios TheocharisAntonios Koutselinis
Clinical Immunology : the Official Journal of the Clinical Immunology Society
Josué PadillaRichard P Phipps
© 2021 Meta ULC. All rights reserved