PMID: 8938447Nov 1, 1996Paper

Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: a possible contributor to the holoprosencephaly 3 phenotype

Genomics
M MackayAnthony J Harmar

Abstract

The neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) have been shown to act on a wide range of tissue and cell types, both in the central nervous system and in the periphery. Two distinct receptors for VIP, the VIP receptor type 1 (VIPR1) and the VIP receptor type 2 (VIPR2), have recently been cloned, each of which binds PACAP and VIP with equal affinity. We report here the chromosomal mapping of the human and mouse VIPR2 genes by fluorescence in situ hybridization. The VIPR2 gene maps to the human chromosomal region 7q36.3 and to the F2 region of mouse chromosome 12. Our localization of the human gene places it in the region where the locus for the craniofacial defect holoprosencephaly type 3 (HPE3) maps. Further mapping experiments, carried out on cell lines derived from patients with HPE or HPE microforms and associated 7q deletions, have led us to redefine the distal extent of the HPE3 minimal critical region, originally characterized by Gurrieri et al. (1993, Nature Genet. 3: 247-251.) The VIPR2 gene lies within this new HPE3 minimal critical region. Our results suggest that deletion of the VIPR2 gene is not the sole factor responsible for the HPE3 phenotype. ...Continue Reading

Citations

Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·E J GoetzlA J Harmar
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·S ShenA J Harmar
Jun 1, 2004·Pharmacological Reviews·Mario DelgadoDoina Ganea
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J K VoiceE J Goetzl
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Colette M JohnstonAnne E Corcoran
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia K VoiceEdward J Goetzl
Dec 9, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·E H LeiterA L Notkins
Feb 24, 2001·Annals of the New York Academy of Sciences·G DorsamE J Goetzl

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