PMID: 9632173Jun 19, 1998Paper

Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients

American Journal of Medical Genetics
A Maassen VanDenBrinkRune R Frants

Abstract

The 5-HT1F receptor, which is present in both human vascular and neuronal tissue, may mediate the therapeutic effect and/or side-effects of sumatriptan. We investigated the chromosomal localization of the 5-HT1F receptor gene and the relation between eventually existing polymorphisms and the clinical response to sumatriptan in migraine patients. The 5-HT1F receptor gene was localized using a monochromosomal mapping panel, followed by a radiation-reduced hybrid mapping and fluorescent in situ hybridization. The results of these techniques show that the 5-HT1F receptor gene is localized at 3p12. We investigated the presence of polymorphisms by single strand conformation polymorphism analysis in 14 migraine patients who consistently responded well to sumatriptan, 12 patients who consistently experienced recurrence of the headache after initial relief, 12 patients with no response to sumatriptan, and in 13 patients who consistently experienced chest symptoms after use of sumatriptan. No polymorphisms were detected in any of the patients. We therefore conclude that genetic diversity of the 5-HT1F receptor gene is most probably not responsible for the variable clinical response to sumatriptan.

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Citations

Mar 15, 2014·Pharmacogenomics·Michele VianaCherubino Di Lorenzo
Dec 15, 2010·Expert Opinion on Drug Metabolism & Toxicology·Giovanna GentilePaolo Martelletti
Jan 25, 2008·The Journal of Headache and Pain·Peer Tfelt-Hansen, Kim Brøsen
Jun 15, 2007·The Journal of Headache and Pain·Carlo AsuniMaria E Stochino
Jul 23, 2008·Neuropharmacology·Antoinette MaassenVanDenBrinkCarlos M Villalón
Nov 14, 2008·Headache·Peter J Goadsby, Richard Hargreaves
Jul 27, 2006·Headache·Boukje De VriesMichel D Ferrari
Jun 14, 2008·Headache·Peter J Goadsby, Richard Hargreaves
Nov 1, 2007·Cephalalgia : an International Journal of Headache·E Hamel
May 19, 2000·Cephalalgia : an International Journal of Headache·P Montagna
Sep 27, 2003·Cephalalgia : an International Journal of Headache·N M RamadanK W Johnson
Sep 27, 2018·Journal of Clinical Pharmacology·Sarah CargninSalvatore Terrazzino
Jul 21, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Alja VideticRadovan Komel
Sep 2, 2008·Expert Review of Neurotherapeutics·Pasquale Montagna
Jun 7, 2011·Journal of Neural Transmission·Arpád PárdutzLászló Vécsei
May 13, 2006·The Journal of Pharmacology and Experimental Therapeutics·Brianne WeissDavid Bleakman

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