Chromosomal passengers: the four-dimensional regulation of mitotic events

Chromosoma
Paola Vagnarelli, William C Earnshaw

Abstract

Chromosomal passengers are proteins that are involved in coordinating the chromosomal and cytoskeletal events of mitosis. The passengers are present in cells as a complex with at least four members: Aurora B, a protein kinase; inner centromeric protein, an activation and targeting subunit; Survivin (function unknown) and Borealin (function also unknown). The kinase is activated at the onset of mitosis, at least partly accomplished by regulation of the levels of its constituents. As mitosis progresses, the kinase complex moves to a highly choreographed series of locations in the mitotic cell, activating key substrates at precise locations and specific times. Functions that require chromosomal passenger activity include chromatin modification (phosphorylation of histone H3), correction of kinetochore attachment errors, aspects of the spindle assembly checkpoint, assembly of a stable bipolar spindle and the completion of cytokinesis. The chromosomal passenger complex provides an essential mechanism for mitotic regulation.

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Citations

Jul 14, 2005·Chromosoma·Jeffrey M Craig, K H Andy Choo
Mar 28, 2006·Chromosoma·Asta VarisMarko J Kallio
Oct 6, 2006·Chromosoma·W RensM A Ferguson-Smith
Jun 19, 2013·Chromosoma·Anna-Leena Salmela, Marko J Kallio
Apr 2, 2008·Cell Research·Alexey E Granovsky, Marsha Rich Rosner
Feb 2, 2006·Nature Cell Biology·Mar Carmena, William C Earnshaw
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Jun 30, 2009·The Journal of Biological Chemistry·Jing LiuXuebiao Yao
Aug 26, 2009·The Journal of Biological Chemistry·Heather BeamishBrian Gabrielli
Oct 8, 2009·The Journal of Biological Chemistry·Henriette FranzWolfgang Fischle
Oct 20, 2010·The Journal of Biological Chemistry·Zhenjie XuWilliam C Earnshaw
Sep 20, 2008·The Journal of Biological Chemistry·Lin-Yu LuJunjie Chen
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