Chromosomal radiosensitivity in head and neck cancer patients: evidence for genetic predisposition?

British Journal of Cancer
K De RuyckH Thierens

Abstract

The association between chromosomal radiosensitivity and genetic predisposition to head and neck cancer was investigated in this study. In all, 101 head and neck cancer patients and 75 healthy control individuals were included in the study. The G(2) assay was used to measure chromosomal radiosensitivity. The results demonstrated that head and neck cancer patients had a statistically higher number of radiation-induced chromatid breaks than controls, with mean values of 1.23 and 1.10 breaks per cell, respectively (P<0.001). Using the 90th percentile of the G(2) scores of the healthy individuals as a cutoff value for chromosomal radiosensitivity, 26% of the cancer patients were radiosensitive compared with 9% of the healthy controls (P=0.008). The mean number of radiation-induced chromatid breaks and the proportion of radiosensitive individuals were highest for oral cavity cancer patients (1.26 breaks per cell, 38%) and pharynx cancer patients (1.27 breaks per cell, 35%). The difference between patients and controls was most pronounced in the lower age group (<or=50 years, 1.32 breaks per cell, 38%) and in the non- and light smoking patient group (<or=10 pack-years, 1.28 breaks per cell, 46%). In conclusion, enhanced chromosomal r...Continue Reading

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Citations

Mar 17, 2012·Mutagenesis·Gillian B CurwenJohn D Boice
Jun 19, 2015·The British Journal of Radiology·J E ScaifeN G Burnet
Mar 25, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hye Min ChoNam-Pyo Cho

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Methods Mentioned

BETA
chromosomal aberrations

Software Mentioned

SPSS

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