Abstract
A small fraction of those individuals exposed to cytotoxic chemotherapy or radiation for the treatment of a primary malignant disease will develop a second malignancy some time later. Although exposure to the cytotoxic agents is believed to be the causative factor, the reason only certain individuals develop the second malignancy is unknown. Some studies have suggested that these individuals might be predisposed to cancer because of an inherent sensitivity to the alkylating agents used in cancer therapy. We have reported that these individuals with therapy-related acute nonlymphocytic leukemia (t-ANLL) have reduced endogenous levels of the repair protein O6-alkylguanine alkyltransferase (AGT). To further investigate the etiology of this disease, alkylation-induced sister-chromatid exchange (SCE) formation in individuals who developed second malignancies, was compared to other patient groups and normal controls. Peripheral blood lymphocytes from patients with (1) t-ANLL, (2) primary forms of acute nonlymphocytic leukemia (ANLL de novo), (3) patients with primary malignancies at risk of developing secondary disease, and (4) unexposed, healthy controls were treated in vitro with N-methyl-N'-nitro-nitrosoguanidine or mitomycin C. B...Continue Reading
References
Dec 10, 1975·Chromosoma·K GotoT Sugiyama
Jul 1, 1978·Cancer·J W VardimanD Variakojis
Feb 23, 1978·Nature·R B Setlow
Jan 1, 1978·Annual Review of Genetics·C F Arlett, A R Lehmann
Feb 1, 1979·Experimental Cell Research·P E Crossen, W F Morgan
Oct 15, 1976·Experimental Cell Research·R TiceJ M Rary
Sep 1, 1987·Mutation Research·M IkenagaA Shima
Jul 1, 1987·Mutation Research·H MitaniH Takebe
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L SamsonE A Waldstein
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B DempleT Lindahl
Sep 1, 1985·Mutation Research·V Bohr, L Køber
Sep 13, 1974·Nature·P Perry, S Wolff
Dec 25, 1980·Nature·R S DayG D Bynum
Aug 1, 1984·Carcinogenesis·B MyrnesH Krokan
Jan 1, 1980·Environmental Mutagenesis·J L Schwartz, M E Gaulden
Feb 22, 1982·Mutation Research·J L SchwartzS Wolff
Citations
Dec 18, 2001·Teratogenesis, Carcinogenesis, and Mutagenesis·H AcarD A Largaespada
Apr 1, 1992·Mutation Research·R R TiceW P Peters
Sep 1, 1990·Mutation Research·O RigaudH Magdelenat
Aug 1, 1991·Mutation Research·L MiglioreE Brunori
Apr 7, 2012·Leukemia Research·Julia RanklHeinz Sill
May 18, 2007·DNA Repair·Ida CasorelliMargherita Bignami
Apr 7, 2000·Carcinogenesis·N RajeswariA Khar
Mar 23, 2001·Journal of Toxicology and Environmental Health. Part a·M G JakabA Tompa