PMID: 11922429Apr 2, 2002Paper

Chromosomal size variation in Trypanosoma cruzi is mainly progressive and is evolutionarily informative

Parasitology
J HenrikssonA Solari

Abstract

The evolutionary significance of chromosome size polymorphism was explored in a representative panel of 26 Trypanosoma cruzi stocks. We tested a progressive model (aCSDI) assuming that the larger the size difference between homologous chromosomes, the more divergent the parasites are. This was contrasted with a non-progressive model (Jaccard's distance), in which any chromosome size difference has the same weight. ACSDI-based dendrograms were very similar to those built-up from multilocus enzyme electrophoresis (MLEE) and random amplified polymorphic DNA (RAPD) data: structuring in 2 major lineages (T. cruzi I and T. cruz II) and 5 small subdivisions within T. cruzi II was identical, and branching was very similar. Furthermore, a significant correlation (P < 0.001) was observed between aCSDI and phenetic distances calculated from MLEE and RAPD data. In contrast, analysis of chromosome size polymorphism with Jaccard's distance generated dendrograms with relatively long branches, causing most branching points to cluster close together, which generates statistically uncertain branching points. Our results thus support a model of progressive chromosome size-variation and show that despite an extensive polymorphism, chromosomal size...Continue Reading

Citations

Apr 3, 2003·International Journal for Parasitology·Nancy R SturmDavid A Campbell
Jun 12, 2003·Molecular and Biochemical Parasitology·Aurélio PedrosoBianca Zingales
May 10, 2003·Microbes and Infection·Carlos A Buscaglia, Javier M Di Noia
Nov 1, 2008·Nucleic Acids Research·Alejandro A AckermannFernán Agüero
Aug 23, 2011·PloS One·Renata T SouzaJosé Franco da Silveira
Jul 15, 2015·Expert Review of Anti-infective Therapy·Louisa A MessengerCaryn Bern
Feb 3, 2007·Experimental Parasitology·Aurélio PedrosoBianca Zingales
Oct 27, 2004·Molecular and Biochemical Parasitology·Nancy VargasBianca Zingales
Feb 17, 2006·Molecular and Biochemical Parasitology·Carole BrancheBjörn Andersson
Sep 25, 2007·Cadernos de saúde pública·Fernanda da Silva Manoel-Caetano, Ana Elizabete Silva
Oct 15, 2009·Future Microbiology·Maria Carolina EliasSergio Schenkman
Dec 23, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jean-Claude Dujardin

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