Chromosomal sublocalization of the human p97 melanoma antigen

Human Genetics
M M Le BeauJ D Rowley

Abstract

The antigen p97 is a tumor-associated antigen that was first identified in human melanomas using monoclonal antibodies. Recently, p97 mRNA was purified and cloned, and a p97 cDNA clone was synthesized. By using the technique of in situ chromosomal hybridization, we have localized the p97 gene to human chromosome No. 3, at bands q28 to q29. p97 belongs to a superfamily of iron-binding proteins that have amino acid homology; other members of this family include transferrin (TF), lactotransferrin, and ovotransferrin. Based upon the shared amino acid homology and upon the observation that the nucleotide sequence is internally duplicated in these genes, it has been proposed that the TF superfamily arose from a common ancestral duplicated gene. The TF gene has also been mapped to the long arm of chromosome No. 3 at bands q21 to q23.

References

Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M M Le BeauJ D Rowley
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T M RoseJ P Brown
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·I ParkM M Zakin
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J P BrownK E Hellström
Feb 15, 1981·International Journal of Cancer. Journal International Du Cancer·R G WoodburyI Hellström
Nov 18, 1983·Science·P LederR Taub
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F YangB H Bowman
Jan 1, 1983·Cytogenetics and Cell Genetics·F Mitelman
Jan 1, 1982·Advances in Cancer Research·J D Rowley, J R Testa
Feb 1, 1982·European Journal of Biochemistry·J WilliamsK A Kuhn
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R G WoodburyK E Hellström
Feb 1, 1982·European Journal of Biochemistry·J M Jeltsch, P Chambon

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